Detailed information of TA system TA252012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1027977..1028791
• Replicon: chromosome
• Accession: NZ_CP101376
• Organism: Salmonella enterica strain SC2016091

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: NMU34_RS04950
• Protein ID: WP_000971655.1
• Coordinates: 1027977..1028504 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: E8XL32
• Locus tag: NMU34_RS04955
• Protein ID: WP_000855692.1
• Coordinates: 1028501..1028791 (-)
• Length: 97 a.a.

Genomic Context

Location: 1026003..1026524 (522 bp)
Type: Others
Protein ID: WP_000858988.1

Location: 1027699..1027904 (206 bp)
Type: Others
Protein ID: Protein_970

Location: 1029480..1029806 (327 bp)
Type: Others
Protein ID: WP_000393302.1

Location: 1032191..1032841 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 1023277..1025844 (2568 bp)
Type: Others
Protein ID: WP_001005807.1

Location: 1026696..1027352 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 1027977..1028504 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 1028501..1028791 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1

Location: 1029061..1029239 (179 bp)
Type: Others
Protein ID: Protein_973

Location: 1030079..1030426 (348 bp)
Type: Others
Protein ID: WP_001669174.1

Location: 1030411..1030860 (450 bp)
Type: Others
Protein ID: WP_000381610.1

Location: 1031291..1031734 (444 bp)
Type: Others
Protein ID: WP_000715092.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMU34_RS04930 (1023277)	1023277..1025844	-	2568	WP_001005807.1	DNA mismatch repair protein MutS	-
NMU34_RS04935 (1026003)	1026003..1026524	+	522	WP_000858988.1	hypothetical protein	-
NMU34_RS04940 (1026696)	1026696..1027352	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
NMU34_RS04945 (1027699)	1027699..1027904	+	206	Protein_970	IS5/IS1182 family transposase	-
NMU34_RS04950 (1027977)	1027977..1028504	-	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
NMU34_RS04955 (1028501)	1028501..1028791	-	291	WP_000855692.1	DUF1778 domain-containing protein	Antitoxin
NMU34_RS04960 (1029061)	1029061..1029239	-	179	Protein_973	IS3 family transposase	-
NMU34_RS04965 (1029480)	1029480..1029806	+	327	WP_000393302.1	hypothetical protein	-
NMU34_RS04970 (1030079)	1030079..1030426	-	348	WP_001669174.1	DUF1493 family protein	-
NMU34_RS04975 (1030411)	1030411..1030860	-	450	WP_000381610.1	membrane protein	-
NMU34_RS04980 (1031291)	1031291..1031734	-	444	WP_000715092.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
NMU34_RS04985 (1032191)	1032191..1032841	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 Genomic island TA010052 4599654..4610080 0	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1027728..1038154	10426
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0	flank	IS/Tn	-	-	1027728..1027904	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T252012 WP_000971655.1 NZ_CP101376:c1028504-1027977 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.57 Da
• Isoelectric Point: 8.5779

>AT252012 WP_000855692.1 NZ_CP101376:c1028791-1028501 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• PDB: 6G96
• PDB: 7AK9

Antitoxin

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• PDB: 7AK9
• AlphaFold DB: A0A625WHV3