Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027977..1028791 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU34_RS04950 Protein ID WP_000971655.1
Coordinates 1027977..1028504 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU34_RS04955 Protein ID WP_000855692.1
Coordinates 1028501..1028791 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS04930 (1023277) 1023277..1025844 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU34_RS04935 (1026003) 1026003..1026524 + 522 WP_000858988.1 hypothetical protein -
NMU34_RS04940 (1026696) 1026696..1027352 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU34_RS04945 (1027699) 1027699..1027904 + 206 Protein_970 IS5/IS1182 family transposase -
NMU34_RS04950 (1027977) 1027977..1028504 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU34_RS04955 (1028501) 1028501..1028791 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU34_RS04960 (1029061) 1029061..1029239 - 179 Protein_973 IS3 family transposase -
NMU34_RS04965 (1029480) 1029480..1029806 + 327 WP_000393302.1 hypothetical protein -
NMU34_RS04970 (1030079) 1030079..1030426 - 348 WP_001669174.1 DUF1493 family protein -
NMU34_RS04975 (1030411) 1030411..1030860 - 450 WP_000381610.1 membrane protein -
NMU34_RS04980 (1031291) 1031291..1031734 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU34_RS04985 (1032191) 1032191..1032841 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027728..1038154 10426
flank IS/Tn - - 1027728..1027904 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T252012 WP_000971655.1 NZ_CP101376:c1028504-1027977 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT252012 WP_000855692.1 NZ_CP101376:c1028791-1028501 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References