187604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1466920..1467734 Replicon chromosome
Accession NZ_CP068696
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag JKV46_RS07160 Protein ID WP_000971655.1
Coordinates 1466920..1467447 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag JKV46_RS07165 Protein ID WP_000855692.1
Coordinates 1467444..1467734 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV46_RS07140 (1462220) 1462220..1464787 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
JKV46_RS07145 (1464946) 1464946..1465467 + 522 WP_000858988.1 hypothetical protein -
JKV46_RS07150 (1465639) 1465639..1466295 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
JKV46_RS07155 (1466642) 1466642..1466847 + 206 Protein_1387 IS5/IS1182 family transposase -
JKV46_RS07160 (1466920) 1466920..1467447 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
JKV46_RS07165 (1467444) 1467444..1467734 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
JKV46_RS07170 (1468004) 1468004..1468182 - 179 Protein_1390 IS3 family transposase -
JKV46_RS07175 (1468423) 1468423..1468749 + 327 WP_000393302.1 hypothetical protein -
JKV46_RS07180 (1469022) 1469022..1469369 - 348 WP_001669174.1 DUF1493 family protein -
JKV46_RS07185 (1469354) 1469354..1469803 - 450 WP_000381610.1 membrane protein -
JKV46_RS07190 (1470234) 1470234..1470677 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JKV46_RS07195 (1471134) 1471134..1471784 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1466671..1477097 10426
flank IS/Tn - - 1466671..1466847 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T187604 WP_000971655.1 NZ_CP068696:c1467447-1466920 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T187604 NZ_CP089927:c1902212-1901889 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT187604 WP_000855692.1 NZ_CP068696:c1467734-1467444 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT187604 NZ_CP089927:c1902537-1902292 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References