251133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028068..1028882 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL735_RS04950 Protein ID WP_000971655.1
Coordinates 1028068..1028595 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NL735_RS04955 Protein ID WP_000855692.1
Coordinates 1028592..1028882 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS04930 (1023368) 1023368..1025935 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NL735_RS04935 (1026094) 1026094..1026615 + 522 WP_000858988.1 hypothetical protein -
NL735_RS04940 (1026787) 1026787..1027443 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL735_RS04945 (1027790) 1027790..1027995 + 206 Protein_970 IS5/IS1182 family transposase -
NL735_RS04950 (1028068) 1028068..1028595 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL735_RS04955 (1028592) 1028592..1028882 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NL735_RS04960 (1029152) 1029152..1029330 - 179 Protein_973 IS3 family transposase -
NL735_RS04965 (1029571) 1029571..1029897 + 327 WP_000393302.1 hypothetical protein -
NL735_RS04970 (1030170) 1030170..1030517 - 348 WP_001669174.1 DUF1493 family protein -
NL735_RS04975 (1030502) 1030502..1030951 - 450 WP_000381610.1 membrane protein -
NL735_RS04980 (1031382) 1031382..1031825 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL735_RS04985 (1032282) 1032282..1032932 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027819..1038245 10426
flank IS/Tn - - 1027819..1027995 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251133 WP_000971655.1 NZ_CP100707:c1028595-1028068 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251133 WP_000855692.1 NZ_CP100707:c1028882-1028592 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References