221686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3420758..3421572 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF46_RS16800 Protein ID WP_000971655.1
Coordinates 3421045..3421572 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF46_RS16795 Protein ID WP_000855694.1
Coordinates 3420758..3421048 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS16775 (3416661) 3416661..3418349 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
LJF46_RS16780 (3418346) 3418346..3418996 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF46_RS16785 (3419452) 3419452..3419895 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF46_RS16790 (3420299) 3420299..3420488 + 190 Protein_3270 IS3 family transposase -
LJF46_RS16795 (3420758) 3420758..3421048 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF46_RS16800 (3421045) 3421045..3421572 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF46_RS16805 (3421645) 3421645..3421850 - 206 Protein_3273 IS5/IS1182 family transposase -
LJF46_RS16810 (3422209) 3422209..3422865 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF46_RS16815 (3423110) 3423110..3423604 - 495 WP_000424949.1 hypothetical protein -
LJF46_RS16820 (3423631) 3423631..3424299 - 669 WP_000445914.1 hypothetical protein -
LJF46_RS16825 (3424885) 3424885..3425283 - 399 Protein_3277 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3421645..3421821 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221686 WP_000971655.1 NZ_CP085806:3421045-3421572 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221686 NZ_CP117568:c2258475-2258161 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221686 WP_000855694.1 NZ_CP085806:3420758-3421048 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221686 NZ_CP117568:c2258164-2257748 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGTCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
ATCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References