Detailed information of TA system TA221686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3420758..3421572
• Replicon: chromosome
• Accession: NZ_CP085806
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: LJF46_RS16800
• Protein ID: WP_000971655.1
• Coordinates: 3421045..3421572 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: LJF46_RS16795
• Protein ID: WP_000855694.1
• Coordinates: 3420758..3421048 (+)
• Length: 97 a.a.

Genomic Context

Location: 3419452..3419895 (444 bp)
Type: Others
Protein ID: WP_000715097.1

Location: 3420299..3420488 (190 bp)
Type: Others
Protein ID: Protein_3270

Location: 3420758..3421048 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1

Location: 3421045..3421572 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 3422209..3422865 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 3416661..3418349 (1689 bp)
Type: Others
Protein ID: WP_000848113.1

Location: 3418346..3418996 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 3421645..3421850 (206 bp)
Type: Others
Protein ID: Protein_3273

Location: 3423110..3423604 (495 bp)
Type: Others
Protein ID: WP_000424949.1

Location: 3423631..3424299 (669 bp)
Type: Others
Protein ID: WP_000445914.1

Location: 3424885..3425283 (399 bp)
Type: Others
Protein ID: Protein_3277

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF46_RS16775 (3416661)	3416661..3418349	-	1689	WP_000848113.1	type III secretion system outer membrane ring protein InvG	-
LJF46_RS16780 (3418346)	3418346..3418996	-	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-
LJF46_RS16785 (3419452)	3419452..3419895	+	444	WP_000715097.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
LJF46_RS16790 (3420299)	3420299..3420488	+	190	Protein_3270	IS3 family transposase	-
LJF46_RS16795 (3420758)	3420758..3421048	+	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
LJF46_RS16800 (3421045)	3421045..3421572	+	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
LJF46_RS16805 (3421645)	3421645..3421850	-	206	Protein_3273	IS5/IS1182 family transposase	-
LJF46_RS16810 (3422209)	3422209..3422865	+	657	WP_000420452.1	protein-serine/threonine phosphatase	-
LJF46_RS16815 (3423110)	3423110..3423604	-	495	WP_000424949.1	hypothetical protein	-
LJF46_RS16820 (3423631)	3423631..3424299	-	669	WP_000445914.1	hypothetical protein	-
LJF46_RS16825 (3424885)	3424885..3425283	-	399	Protein_3277	cytoplasmic protein	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0.007 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0.007 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0.007	flank	IS/Tn	-	-	3421645..3421821	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T221686 WP_000971655.1 NZ_CP085806:3421045-3421572 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T221686 NZ_CP117568:c2258475-2258161 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT221686 WP_000855694.1 NZ_CP085806:3420758-3421048 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT221686 NZ_CP117568:c2258164-2257748 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGTCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
ATCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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• PDB: 6G96
• PDB: 7AK9

Antitoxin

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• AlphaFold DB: A0A3V8SJE7