170667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3272248..3273062 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q84_RS16045 Protein ID WP_000971655.1
Coordinates 3272535..3273062 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q84_RS16040 Protein ID WP_000855694.1
Coordinates 3272248..3272538 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS16020 (3268151) 3268151..3269839 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
H9Q84_RS16025 (3269836) 3269836..3270486 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
H9Q84_RS16030 (3270942) 3270942..3271385 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
H9Q84_RS16035 (3271789) 3271789..3271978 + 190 Protein_3132 IS3 family transposase -
H9Q84_RS16040 (3272248) 3272248..3272538 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
H9Q84_RS16045 (3272535) 3272535..3273062 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
H9Q84_RS16050 (3273135) 3273135..3273340 - 206 Protein_3135 IS5/IS1182 family transposase -
H9Q84_RS16055 (3273699) 3273699..3274355 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
H9Q84_RS16060 (3274600) 3274600..3275094 - 495 WP_000424949.1 hypothetical protein -
H9Q84_RS16065 (3275121) 3275121..3275789 - 669 WP_000445914.1 hypothetical protein -
H9Q84_RS16070 (3276375) 3276375..3276773 - 399 Protein_3139 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3273135..3273311 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170667 WP_000971655.1 NZ_CP060674:3272535-3273062 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170667 NZ_CP077670:3577067-3577318 [Salmonella enterica]
ATGCGGGATACTTACAAAACCCACATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGC
AGAAGCGGGATTTGATACCGGGGCGAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACG
AAGTGAGGGATCTACGGAGGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTG
AACGGGAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170667 WP_000855694.1 NZ_CP060674:3272248-3272538 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170667 NZ_CP077670:c3577308-3577083 [Salmonella enterica]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References