Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3272248..3273062 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q84_RS16045 Protein ID WP_000971655.1
Coordinates 3272535..3273062 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q84_RS16040 Protein ID WP_000855694.1
Coordinates 3272248..3272538 (+) Length 97 a.a.

Genomic Context

H9Q84_RS16030H9Q84_RS16035H9Q84_RS16040H9Q84_RS16045H9Q84_RS16055H9Q84_RS16020H9Q84_RS16025H9Q84_RS16050H9Q84_RS16060H9Q84_RS16065H9Q84_RS16070
Location: 3270942..3271385 (444 bp)
Type: Others
Protein ID: WP_000715097.1
Location: 3271789..3271978 (190 bp)
Type: Others
Protein ID: Protein_3132
Location: 3272248..3272538 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 3272535..3273062 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3273699..3274355 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3268151..3269839 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 3269836..3270486 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3273135..3273340 (206 bp)
Type: Others
Protein ID: Protein_3135
Location: 3274600..3275094 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 3275121..3275789 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 3276375..3276773 (399 bp)
Type: Others
Protein ID: Protein_3139
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9Q84_RS16020 (3268151)3268151..3269839-1689WP_000848113.1type III secretion system outer membrane ring protein InvG-
H9Q84_RS16025 (3269836)3269836..3270486-651WP_001674874.1type III secretion system transcriptional activator InvF-
H9Q84_RS16030 (3270942)3270942..3271385+444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
H9Q84_RS16035 (3271789)3271789..3271978+190Protein_3132IS3 family transposase-
H9Q84_RS16040 (3272248)3272248..3272538+291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
H9Q84_RS16045 (3272535)3272535..3273062+528WP_000971655.1GNAT family N-acetyltransferaseToxin
H9Q84_RS16050 (3273135)3273135..3273340-206Protein_3135IS5/IS1182 family transposase-
H9Q84_RS16055 (3273699)3273699..3274355+657WP_000420452.1protein-serine/threonine phosphatase-
H9Q84_RS16060 (3274600)3274600..3275094-495WP_000424949.1hypothetical protein-
H9Q84_RS16065 (3275121)3275121..3275789-669WP_000445914.1hypothetical protein-
H9Q84_RS16070 (3276375)3276375..3276773-399Protein_3139cytoplasmic protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3273135..3273311176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170667 WP_000971655.1 NZ_CP060674:3272535-3273062 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170667 NZ_CP077670:3577067-3577318 [Salmonella enterica]
ATGCGGGATACTTACAAAACCCACATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGC
AGAAGCGGGATTTGATACCGGGGCGAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACG
AAGTGAGGGATCTACGGAGGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTG
AACGGGAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170667 WP_000855694.1 NZ_CP060674:3272248-3272538 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170667 NZ_CP077670:c3577308-3577083 [Salmonella enterica]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References