233703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1031141..1031955 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN80_RS04970 Protein ID WP_000971655.1
Coordinates 1031141..1031668 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN80_RS04975 Protein ID WP_000855692.1
Coordinates 1031665..1031955 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS04950 (1026441) 1026441..1029008 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
INN80_RS04955 (1029167) 1029167..1029688 + 522 WP_000858988.1 hypothetical protein -
INN80_RS04960 (1029860) 1029860..1030516 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN80_RS04965 (1030863) 1030863..1031068 + 206 Protein_977 IS5/IS1182 family transposase -
INN80_RS04970 (1031141) 1031141..1031668 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN80_RS04975 (1031665) 1031665..1031955 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN80_RS04980 (1032225) 1032225..1032403 - 179 Protein_980 IS3 family transposase -
INN80_RS04985 (1032644) 1032644..1032970 + 327 WP_000393302.1 hypothetical protein -
INN80_RS04990 (1033243) 1033243..1033590 - 348 WP_001669174.1 DUF1493 family protein -
INN80_RS04995 (1033575) 1033575..1034024 - 450 WP_000381610.1 membrane protein -
INN80_RS05000 (1034455) 1034455..1034898 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN80_RS05005 (1035355) 1035355..1036005 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1030892..1041318 10426
flank IS/Tn - - 1030892..1031068 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233703 WP_000971655.1 NZ_CP091556:c1031668-1031141 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233703 NZ_LM995446:2719981-2720310 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233703 WP_000855692.1 NZ_CP091556:c1031955-1031665 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233703 NZ_LM995446:2719643-2719960 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References