265955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1024214..1025028 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OXV06_RS04875 Protein ID WP_000971655.1
Coordinates 1024214..1024741 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OXV06_RS04880 Protein ID WP_000855692.1
Coordinates 1024738..1025028 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS04855 (1019514) 1019514..1022081 - 2568 WP_198903237.1 DNA mismatch repair protein MutS -
OXV06_RS04860 (1022240) 1022240..1022761 + 522 WP_000858988.1 hypothetical protein -
OXV06_RS04865 (1022933) 1022933..1023589 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
OXV06_RS04870 (1023936) 1023936..1024141 + 206 Protein_955 IS5/IS1182 family transposase -
OXV06_RS04875 (1024214) 1024214..1024741 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OXV06_RS04880 (1024738) 1024738..1025028 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OXV06_RS04885 (1025298) 1025298..1025476 - 179 Protein_958 IS3 family transposase -
OXV06_RS04890 (1025717) 1025717..1026043 + 327 WP_000393302.1 hypothetical protein -
OXV06_RS04895 (1026316) 1026316..1026663 - 348 WP_001669174.1 DUF1493 family protein -
OXV06_RS04900 (1026648) 1026648..1027097 - 450 WP_000381610.1 membrane protein -
OXV06_RS04905 (1027528) 1027528..1027971 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OXV06_RS04910 (1028428) 1028428..1029078 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1024214..1034391 10177
inside Genomic island - invH / invF / invG / invE / invA / invB 1023965..1034391 10426
flank IS/Tn - - 1023965..1024141 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T265955 WP_000971655.1 NZ_CP113538:c1024741-1024214 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT265955 WP_000855692.1 NZ_CP113538:c1025028-1024738 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References