251952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1370889..1371703 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU31_RS06755 Protein ID WP_000971655.1
Coordinates 1370889..1371416 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU31_RS06760 Protein ID WP_000855692.1
Coordinates 1371413..1371703 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS06735 (1366189) 1366189..1368756 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU31_RS06740 (1368915) 1368915..1369436 + 522 WP_000858988.1 hypothetical protein -
NMU31_RS06745 (1369608) 1369608..1370264 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU31_RS06750 (1370611) 1370611..1370816 + 206 Protein_1331 IS5/IS1182 family transposase -
NMU31_RS06755 (1370889) 1370889..1371416 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU31_RS06760 (1371413) 1371413..1371703 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU31_RS06765 (1371973) 1371973..1372151 - 179 Protein_1334 IS3 family transposase -
NMU31_RS06770 (1372392) 1372392..1372718 + 327 WP_000393302.1 hypothetical protein -
NMU31_RS06775 (1372991) 1372991..1373338 - 348 WP_001669174.1 DUF1493 family protein -
NMU31_RS06780 (1373323) 1373323..1373772 - 450 WP_000381610.1 membrane protein -
NMU31_RS06785 (1374203) 1374203..1374646 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU31_RS06790 (1375103) 1375103..1375753 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1370640..1381066 10426
flank IS/Tn - - 1370640..1370816 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251952 WP_000971655.1 NZ_CP101372:c1371416-1370889 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT251952 WP_000855692.1 NZ_CP101372:c1371703-1371413 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References