238561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027889..1028703 Replicon chromosome
Accession NZ_CP093411
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)


Gene name TacT3 Uniprot ID B5F3Y4
Locus tag MOP53_RS04965 Protein ID WP_000971656.1
Coordinates 1027889..1028416 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MOP53_RS04970 Protein ID WP_000855694.1
Coordinates 1028413..1028703 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP53_RS04935 (1024189) 1024189..1024610 + 422 Protein_970 cytoplasmic protein -
MOP53_RS04940 (1024778) 1024778..1025017 + 240 Protein_971 hypothetical protein -
MOP53_RS04945 (1025174) 1025174..1025842 + 669 WP_000445914.1 hypothetical protein -
MOP53_RS04950 (1025869) 1025869..1026363 + 495 WP_000424943.1 hypothetical protein -
MOP53_RS04955 (1026608) 1026608..1027264 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
MOP53_RS04960 (1027614) 1027614..1027816 + 203 Protein_975 IS5/IS1182 family transposase -
MOP53_RS04965 (1027889) 1027889..1028416 - 528 WP_000971656.1 GNAT family N-acetyltransferase Toxin
MOP53_RS04970 (1028413) 1028413..1028703 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MOP53_RS04975 (1029296) 1029296..1029622 + 327 WP_000393296.1 hypothetical protein -
MOP53_RS04980 (1029895) 1029895..1030242 - 348 WP_001555786.1 DUF1493 family protein -
MOP53_RS04985 (1030227) 1030227..1030676 - 450 WP_000381619.1 hypothetical protein -
MOP53_RS04990 (1031108) 1031108..1031551 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MOP53_RS04995 (1032007) 1032007..1032657 + 651 WP_001747511.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1027640..1027816 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19156.98 Da        Isoelectric Point: 9.6420

>T238561 WP_000971656.1 NZ_CP093411:c1028416-1027889 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238561 NZ_LR890395:c2612276-2610954 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT238561 WP_000855694.1 NZ_CP093411:c1028703-1028413 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238561 NZ_LR890395:c2612542-2612276 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3J3UPI2

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References