Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 988501..989315 Replicon chromosome
Accession NZ_CP080091
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KZY40_RS04720 Protein ID WP_000971655.1
Coordinates 988501..989028 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KZY40_RS04725 Protein ID WP_000855694.1
Coordinates 989025..989315 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS04695 (984790) 984790..985188 + 399 Protein_919 cytoplasmic protein -
KZY40_RS04700 (985774) 985774..986442 + 669 WP_000445914.1 hypothetical protein -
KZY40_RS04705 (986469) 986469..986963 + 495 WP_000424949.1 hypothetical protein -
KZY40_RS04710 (987208) 987208..987864 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KZY40_RS04715 (988223) 988223..988428 + 206 Protein_923 IS5/IS1182 family transposase -
KZY40_RS04720 (988501) 988501..989028 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KZY40_RS04725 (989025) 989025..989315 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KZY40_RS04730 (989585) 989585..989774 - 190 Protein_926 IS3 family transposase -
KZY40_RS04735 (990178) 990178..990621 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KZY40_RS04740 (991077) 991077..991727 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
KZY40_RS04745 (991724) 991724..993412 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 988252..988428 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T210724 WP_000971655.1 NZ_CP080091:c989028-988501 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T210724 NZ_CP104598:4302144-4302629 [Escherichia coli]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGAAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT210724 WP_000855694.1 NZ_CP080091:c989315-989025 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT210724 NZ_CP104598:4301875-4302153 [Escherichia coli]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References