Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028985..1029799 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN75_RS04955 Protein ID WP_000971655.1
Coordinates 1028985..1029512 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN75_RS04960 Protein ID WP_000855692.1
Coordinates 1029509..1029799 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS04935 (1024285) 1024285..1026852 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
INN75_RS04940 (1027011) 1027011..1027532 + 522 WP_000858988.1 hypothetical protein -
INN75_RS04945 (1027704) 1027704..1028360 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN75_RS04950 (1028707) 1028707..1028912 + 206 Protein_974 IS5/IS1182 family transposase -
INN75_RS04955 (1028985) 1028985..1029512 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN75_RS04960 (1029509) 1029509..1029799 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN75_RS04965 (1030069) 1030069..1030247 - 179 Protein_977 IS3 family transposase -
INN75_RS04970 (1030488) 1030488..1030814 + 327 WP_000393302.1 hypothetical protein -
INN75_RS04975 (1031087) 1031087..1031434 - 348 WP_001669174.1 DUF1493 family protein -
INN75_RS04980 (1031419) 1031419..1031868 - 450 WP_000381610.1 membrane protein -
INN75_RS04985 (1032299) 1032299..1032742 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN75_RS04990 (1033199) 1033199..1033849 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1028736..1028912 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233835 WP_000971655.1 NZ_CP091569:c1029512-1028985 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233835 NZ_LN831036:c849309-849121 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233835 WP_000855692.1 NZ_CP091569:c1029799-1029509 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233835 NZ_LN831036:c849598-849338 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References