257779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995261..996075 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4533_RS04755 Protein ID WP_000971655.1
Coordinates 995261..995788 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag N4533_RS04760 Protein ID WP_000855692.1
Coordinates 995785..996075 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS04735 (990561) 990561..993128 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
N4533_RS04740 (993287) 993287..993808 + 522 WP_000858988.1 hypothetical protein -
N4533_RS04745 (993980) 993980..994636 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4533_RS04750 (994983) 994983..995188 + 206 Protein_931 IS5/IS1182 family transposase -
N4533_RS04755 (995261) 995261..995788 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4533_RS04760 (995785) 995785..996075 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
N4533_RS04765 (996345) 996345..996523 - 179 Protein_934 IS3 family transposase -
N4533_RS04770 (996764) 996764..997090 + 327 WP_000393302.1 hypothetical protein -
N4533_RS04775 (997363) 997363..997710 - 348 WP_001669174.1 DUF1493 family protein -
N4533_RS04780 (997695) 997695..998144 - 450 WP_000381610.1 membrane protein -
N4533_RS04785 (998575) 998575..999018 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4533_RS04790 (999475) 999475..1000125 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995012..1005438 10426
flank IS/Tn - - 995012..995188 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T257779 WP_000971655.1 NZ_CP104366:c995788-995261 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT257779 WP_000855692.1 NZ_CP104366:c996075-995785 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References