Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3253641..3254455 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K8862_RS15735 Protein ID WP_000971655.1
Coordinates 3253641..3254168 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag K8862_RS15740 Protein ID WP_000855694.1
Coordinates 3254165..3254455 (-) Length 97 a.a.

Genomic Context

K8862_RS15710K8862_RS15715K8862_RS15720K8862_RS15730K8862_RS15755K8862_RS15760K8862_RS15725K8862_RS15735K8862_RS15740K8862_RS15745K8862_RS15750
Location: 3249930..3250328 (399 bp)
Type: Others
Protein ID: Protein_3047
Location: 3250914..3251582 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 3251609..3252103 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 3253363..3253568 (206 bp)
Type: Others
Protein ID: Protein_3051
Location: 3256217..3256867 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3256864..3258552 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 3252348..3253004 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3253641..3254168 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3254165..3254455 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 3254725..3254914 (190 bp)
Type: Others
Protein ID: Protein_3054
Location: 3255318..3255761 (444 bp)
Type: Others
Protein ID: WP_000715097.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8862_RS15710 (3249930)3249930..3250328+399Protein_3047cytoplasmic protein-
K8862_RS15715 (3250914)3250914..3251582+669WP_000445914.1hypothetical protein-
K8862_RS15720 (3251609)3251609..3252103+495WP_000424949.1hypothetical protein-
K8862_RS15725 (3252348)3252348..3253004-657WP_000420452.1protein-serine/threonine phosphatase-
K8862_RS15730 (3253363)3253363..3253568+206Protein_3051IS5/IS1182 family transposase-
K8862_RS15735 (3253641)3253641..3254168-528WP_000971655.1GNAT family N-acetyltransferaseToxin
K8862_RS15740 (3254165)3254165..3254455-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
K8862_RS15745 (3254725)3254725..3254914-190Protein_3054IS3 family transposase-
K8862_RS15750 (3255318)3255318..3255761-444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
K8862_RS15755 (3256217)3256217..3256867+651WP_001674874.1type III secretion system transcriptional activator InvF-
K8862_RS15760 (3256864)3256864..3258552+1689WP_000848113.1type III secretion system outer membrane ring protein InvG-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3253392..3253568176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T215579 WP_000971655.1 NZ_CP082916:c3254168-3253641 [Salmonella enterica subsp. enterica serovar Newlands]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T215579 NZ_CP110816:2233827-2234114 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT215579 WP_000855694.1 NZ_CP082916:c3254455-3254165 [Salmonella enterica subsp. enterica serovar Newlands]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT215579 NZ_CP110816:2233588-2233827 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References