215579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3253641..3254455 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K8862_RS15735 Protein ID WP_000971655.1
Coordinates 3253641..3254168 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag K8862_RS15740 Protein ID WP_000855694.1
Coordinates 3254165..3254455 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS15710 (3249930) 3249930..3250328 + 399 Protein_3047 cytoplasmic protein -
K8862_RS15715 (3250914) 3250914..3251582 + 669 WP_000445914.1 hypothetical protein -
K8862_RS15720 (3251609) 3251609..3252103 + 495 WP_000424949.1 hypothetical protein -
K8862_RS15725 (3252348) 3252348..3253004 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
K8862_RS15730 (3253363) 3253363..3253568 + 206 Protein_3051 IS5/IS1182 family transposase -
K8862_RS15735 (3253641) 3253641..3254168 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
K8862_RS15740 (3254165) 3254165..3254455 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
K8862_RS15745 (3254725) 3254725..3254914 - 190 Protein_3054 IS3 family transposase -
K8862_RS15750 (3255318) 3255318..3255761 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
K8862_RS15755 (3256217) 3256217..3256867 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
K8862_RS15760 (3256864) 3256864..3258552 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3253392..3253568 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T215579 WP_000971655.1 NZ_CP082916:c3254168-3253641 [Salmonella enterica subsp. enterica serovar Newlands]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T215579 NZ_CP110816:2233827-2234114 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT215579 WP_000855694.1 NZ_CP082916:c3254455-3254165 [Salmonella enterica subsp. enterica serovar Newlands]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT215579 NZ_CP110816:2233588-2233827 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References