203514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1077991..1078805 Replicon chromosome
Accession NZ_CP075372
Organism Salmonella enterica strain no75

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KH432_RS05180 Protein ID WP_000971655.1
Coordinates 1077991..1078518 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KH432_RS05185 Protein ID WP_000855692.1
Coordinates 1078515..1078805 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH432_RS05160 (1073291) 1073291..1075858 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
KH432_RS05165 (1076017) 1076017..1076538 + 522 WP_000858988.1 hypothetical protein -
KH432_RS05170 (1076710) 1076710..1077366 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KH432_RS05175 (1077713) 1077713..1077918 + 206 Protein_1020 IS5/IS1182 family transposase -
KH432_RS05180 (1077991) 1077991..1078518 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KH432_RS05185 (1078515) 1078515..1078805 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
KH432_RS05190 (1079075) 1079075..1079253 - 179 Protein_1023 IS3 family transposase -
KH432_RS05195 (1079494) 1079494..1079820 + 327 WP_000393302.1 hypothetical protein -
KH432_RS05200 (1080093) 1080093..1080440 - 348 WP_001669174.1 DUF1493 family protein -
KH432_RS05205 (1080425) 1080425..1080874 - 450 WP_000381610.1 membrane protein -
KH432_RS05210 (1081305) 1081305..1081748 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KH432_RS05215 (1082205) 1082205..1082855 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1077742..1088168 10426
flank IS/Tn - - 1077742..1077918 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T203514 WP_000971655.1 NZ_CP075372:c1078518-1077991 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T203514 NZ_CP100108:c6145-5840 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT203514 WP_000855692.1 NZ_CP075372:c1078805-1078515 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT203514 NZ_CP100108:c6365-6147 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References