Detailed information of TA system TA203514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1077991..1078805
• Replicon: chromosome
• Accession: NZ_CP075372
• Organism: Salmonella enterica strain no75

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: KH432_RS05180
• Protein ID: WP_000971655.1
• Coordinates: 1077991..1078518 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: E8XL32
• Locus tag: KH432_RS05185
• Protein ID: WP_000855692.1
• Coordinates: 1078515..1078805 (-)
• Length: 97 a.a.

Genomic Context

Location: 1076017..1076538 (522 bp)
Type: Others
Protein ID: WP_000858988.1

Location: 1077713..1077918 (206 bp)
Type: Others
Protein ID: Protein_1020

Location: 1079494..1079820 (327 bp)
Type: Others
Protein ID: WP_000393302.1

Location: 1082205..1082855 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 1073291..1075858 (2568 bp)
Type: Others
Protein ID: WP_001005807.1

Location: 1076710..1077366 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 1077991..1078518 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 1078515..1078805 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1

Location: 1079075..1079253 (179 bp)
Type: Others
Protein ID: Protein_1023

Location: 1080093..1080440 (348 bp)
Type: Others
Protein ID: WP_001669174.1

Location: 1080425..1080874 (450 bp)
Type: Others
Protein ID: WP_000381610.1

Location: 1081305..1081748 (444 bp)
Type: Others
Protein ID: WP_000715092.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KH432_RS05160 (1073291)	1073291..1075858	-	2568	WP_001005807.1	DNA mismatch repair protein MutS	-
KH432_RS05165 (1076017)	1076017..1076538	+	522	WP_000858988.1	hypothetical protein	-
KH432_RS05170 (1076710)	1076710..1077366	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
KH432_RS05175 (1077713)	1077713..1077918	+	206	Protein_1020	IS5/IS1182 family transposase	-
KH432_RS05180 (1077991)	1077991..1078518	-	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
KH432_RS05185 (1078515)	1078515..1078805	-	291	WP_000855692.1	DUF1778 domain-containing protein	Antitoxin
KH432_RS05190 (1079075)	1079075..1079253	-	179	Protein_1023	IS3 family transposase	-
KH432_RS05195 (1079494)	1079494..1079820	+	327	WP_000393302.1	hypothetical protein	-
KH432_RS05200 (1080093)	1080093..1080440	-	348	WP_001669174.1	DUF1493 family protein	-
KH432_RS05205 (1080425)	1080425..1080874	-	450	WP_000381610.1	membrane protein	-
KH432_RS05210 (1081305)	1081305..1081748	-	444	WP_000715092.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
KH432_RS05215 (1082205)	1082205..1082855	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 Genomic island TA010052 4599654..4610080 0	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1077742..1088168	10426
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0	flank	IS/Tn	-	-	1077742..1077918	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T203514 WP_000971655.1 NZ_CP075372:c1078518-1077991 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T203514 NZ_CP100108:c6145-5840 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.57 Da
• Isoelectric Point: 8.5779

>AT203514 WP_000855692.1 NZ_CP075372:c1078805-1078515 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT203514 NZ_CP100108:c6365-6147 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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• PDB: 6G96
• PDB: 7AK9

Antitoxin

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• PDB: 7AK9
• AlphaFold DB: A0A625WHV3