Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028866..1029680 Replicon chromosome
Accession NZ_AP023317
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag K5693_RS04955 Protein ID WP_000971655.1
Coordinates 1028866..1029393 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag K5693_RS04960 Protein ID WP_000855692.1
Coordinates 1029390..1029680 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5693_RS04935 (1024166) 1024166..1026733 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
K5693_RS04940 (1026892) 1026892..1027413 + 522 WP_000858988.1 hypothetical protein -
K5693_RS04945 (1027585) 1027585..1028241 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
K5693_RS04950 (1028588) 1028588..1028793 + 206 Protein_972 IS5/IS1182 family transposase -
K5693_RS04955 (1028866) 1028866..1029393 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
K5693_RS04960 (1029390) 1029390..1029680 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
K5693_RS04965 (1029950) 1029950..1030128 - 179 Protein_975 IS3 family transposase -
K5693_RS04970 (1030369) 1030369..1030695 + 327 WP_000393302.1 hypothetical protein -
K5693_RS04975 (1030968) 1030968..1031315 - 348 WP_001669174.1 DUF1493 family protein -
K5693_RS04980 (1031300) 1031300..1031749 - 450 WP_000381610.1 membrane protein -
K5693_RS04985 (1032180) 1032180..1032623 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
K5693_RS04990 (1033080) 1033080..1033730 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1028617..1039043 10426
flank IS/Tn - - 1028617..1028793 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T37556 WP_000971655.1 NZ_AP023317:c1029393-1028866 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T37556 NZ_AP023317:c1029393-1028866 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT37556 WP_000855692.1 NZ_AP023317:c1029680-1029390 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT37556 NZ_AP023317:c1029680-1029390 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References