233789

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3714858..3715672 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN77_RS18450 Protein ID WP_000971655.1
Coordinates 3715145..3715672 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN77_RS18445 Protein ID WP_000855692.1
Coordinates 3714858..3715148 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS18415 (3710808) 3710808..3711458 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
INN77_RS18420 (3711915) 3711915..3712358 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN77_RS18425 (3712789) 3712789..3713238 + 450 WP_000381610.1 membrane protein -
INN77_RS18430 (3713223) 3713223..3713570 + 348 WP_001669174.1 DUF1493 family protein -
INN77_RS18435 (3713843) 3713843..3714169 - 327 WP_000393302.1 hypothetical protein -
INN77_RS18440 (3714410) 3714410..3714588 + 179 Protein_3600 IS3 family transposase -
INN77_RS18445 (3714858) 3714858..3715148 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN77_RS18450 (3715145) 3715145..3715672 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN77_RS18455 (3715745) 3715745..3715950 - 206 Protein_3603 IS5/IS1182 family transposase -
INN77_RS18460 (3716297) 3716297..3716953 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
INN77_RS18465 (3717125) 3717125..3717646 - 522 WP_000858988.1 hypothetical protein -
INN77_RS18470 (3717805) 3717805..3720372 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3715745..3715921 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233789 WP_000971655.1 NZ_CP091563:3715145-3715672 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233789 NZ_LN813019:c2126388-2126089 [Halomonas sp. R57-5]
ATGACGCTATTCACACTTACGCTAGCTGCCAAAATGGATTTAAGAGACATTGCTTTGTTTACTCAGCGCCGTTGGGGTAA
AAAGCAGCGGAACGTCTACTTAAACCAGTTTGATGACTCATTCTGGTTACTGGCAGAAACCCCTGATATCGGAAAATCGT
GTGACGAAATTCGCCAGAATTACCGCAAGTTTCCGCAGGGCAGCCATGTTATTTTTTACCAACAAACCGGAAGCCATAAA
ATAAGAATAATTCGCATATTACACAAGAGCATGGATGTGAACGCCGCCTTTGGTGCATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233789 WP_000855692.1 NZ_CP091563:3714858-3715148 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233789 NZ_LN813019:c2126630-2126388 [Halomonas sp. R57-5]
ATGGCTAAAAATACAAGCATCACACTTGGTGACCACTTTGAAAATTTTGTTACCACTCAAGTACAAAGTGGTCGATACGG
TTCTACGAGCGAAGTCATTCGTTCAGCCCTACGTCTACTCGAAAACCAGGAAACCAAACTACATACACTCAGGCAACTGC
TTATCGAGGGTGAGCAAAGCGGTGACGCTGACTATGACCTCAGCAGCTTTATCAATGAGCTTGATAGTGAAAAAAGTAAC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References