Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3763444..3764258 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1705_RS18535 Protein ID WP_000971655.1
Coordinates 3763731..3764258 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1705_RS18530 Protein ID WP_000855694.1
Coordinates 3763444..3763734 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS18510 (3759347) 3759347..3761035 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
P1705_RS18515 (3761032) 3761032..3761682 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
P1705_RS18520 (3762138) 3762138..3762581 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1705_RS18525 (3762985) 3762985..3763174 + 190 Protein_3582 IS3 family transposase -
P1705_RS18530 (3763444) 3763444..3763734 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1705_RS18535 (3763731) 3763731..3764258 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1705_RS18540 (3764331) 3764331..3764536 - 206 Protein_3585 IS5/IS1182 family transposase -
P1705_RS18545 (3764895) 3764895..3765551 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
P1705_RS18550 (3765796) 3765796..3766290 - 495 WP_000424949.1 hypothetical protein -
P1705_RS18555 (3766317) 3766317..3766985 - 669 WP_000445914.1 hypothetical protein -
P1705_RS18560 (3767571) 3767571..3767969 - 399 Protein_3589 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3764331..3764507 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T274656 WP_000971655.1 NZ_CP120322:3763731-3764258 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274656 WP_000855694.1 NZ_CP120322:3763444-3763734 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References