Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 522650..523464 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF51_RS02520 Protein ID WP_000971655.1
Coordinates 522650..523177 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF51_RS02525 Protein ID WP_000855694.1
Coordinates 523174..523464 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS02495 (518939) 518939..519337 + 399 Protein_481 cytoplasmic protein -
LJF51_RS02500 (519923) 519923..520591 + 669 WP_000445914.1 hypothetical protein -
LJF51_RS02505 (520618) 520618..521112 + 495 WP_000424949.1 hypothetical protein -
LJF51_RS02510 (521357) 521357..522013 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF51_RS02515 (522372) 522372..522577 + 206 Protein_485 IS5/IS1182 family transposase -
LJF51_RS02520 (522650) 522650..523177 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF51_RS02525 (523174) 523174..523464 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF51_RS02530 (523734) 523734..523923 - 190 Protein_488 IS3 family transposase -
LJF51_RS02535 (524327) 524327..524770 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF51_RS02540 (525226) 525226..525876 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF51_RS02545 (525873) 525873..527561 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 522401..522577 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221566 WP_000971655.1 NZ_CP085802:c523177-522650 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221566 NZ_CP117503:c2568125-2568024 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221566 WP_000855694.1 NZ_CP085802:c523464-523174 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221566 NZ_CP117503:2567900-2568079 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References