Detailed information of TA system TA221566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 522650..523464
• Replicon: chromosome
• Accession: NZ_CP085802
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: Q57KM2
• Locus tag: LJF51_RS02520
• Protein ID: WP_000971655.1
• Coordinates: 522650..523177 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: LJF51_RS02525
• Protein ID: WP_000855694.1
• Coordinates: 523174..523464 (-)
• Length: 97 a.a.

Genomic Context

Location: 518939..519337 (399 bp)
Type: Others
Protein ID: Protein_481

Location: 519923..520591 (669 bp)
Type: Others
Protein ID: WP_000445914.1

Location: 520618..521112 (495 bp)
Type: Others
Protein ID: WP_000424949.1

Location: 522372..522577 (206 bp)
Type: Others
Protein ID: Protein_485

Location: 525226..525876 (651 bp)
Type: Others
Protein ID: WP_001674874.1

Location: 525873..527561 (1689 bp)
Type: Others
Protein ID: WP_000848113.1

Location: 521357..522013 (657 bp)
Type: Others
Protein ID: WP_000420452.1

Location: 522650..523177 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1

Location: 523174..523464 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1

Location: 523734..523923 (190 bp)
Type: Others
Protein ID: Protein_488

Location: 524327..524770 (444 bp)
Type: Others
Protein ID: WP_000715097.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF51_RS02495 (518939)	518939..519337	+	399	Protein_481	cytoplasmic protein	-
LJF51_RS02500 (519923)	519923..520591	+	669	WP_000445914.1	hypothetical protein	-
LJF51_RS02505 (520618)	520618..521112	+	495	WP_000424949.1	hypothetical protein	-
LJF51_RS02510 (521357)	521357..522013	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
LJF51_RS02515 (522372)	522372..522577	+	206	Protein_485	IS5/IS1182 family transposase	-
LJF51_RS02520 (522650)	522650..523177	-	528	WP_000971655.1	GNAT family N-acetyltransferase	Toxin
LJF51_RS02525 (523174)	523174..523464	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
LJF51_RS02530 (523734)	523734..523923	-	190	Protein_488	IS3 family transposase	-
LJF51_RS02535 (524327)	524327..524770	-	444	WP_000715097.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
LJF51_RS02540 (525226)	525226..525876	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-
LJF51_RS02545 (525873)	525873..527561	+	1689	WP_000848113.1	type III secretion system outer membrane ring protein InvG	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA025955 3070795..3070971 0.007 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026055 3068456..3068632 0.007 View UFRD01000002 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023 IS/Tn TA010052 4599654..4599830 0.007	flank	IS/Tn	-	-	522401..522577	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19069.91 Da
• Isoelectric Point: 9.6420

>T221566 WP_000971655.1 NZ_CP085802:c523177-522650 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T221566 NZ_CP117503:c2568125-2568024 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT221566 WP_000855694.1 NZ_CP085802:c523464-523174 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT221566 NZ_CP117503:2567900-2568079 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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• PDB: 6G96
• PDB: 7AK9

Antitoxin

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• AlphaFold DB: A0A3V8SJE7