Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3427541..3428355 | Replicon | chromosome |
| Accession | NZ_CP077760 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | B5RDM7 |
| Locus tag | KTV86_RS16515 | Protein ID | WP_000971654.1 |
| Coordinates | 3427541..3428068 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | B5RDM6 |
| Locus tag | KTV86_RS16520 | Protein ID | WP_000855693.1 |
| Coordinates | 3428065..3428355 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTV86_RS16490 (3423830) | 3423830..3424228 | + | 399 | Protein_3217 | cytoplasmic protein | - |
| KTV86_RS16495 (3424814) | 3424814..3425482 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| KTV86_RS16500 (3425509) | 3425509..3426003 | + | 495 | WP_000424940.1 | hypothetical protein | - |
| KTV86_RS16505 (3426248) | 3426248..3426904 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| KTV86_RS16510 (3427263) | 3427263..3427468 | + | 206 | Protein_3221 | IS5/IS1182 family transposase | - |
| KTV86_RS16515 (3427541) | 3427541..3428068 | - | 528 | WP_000971654.1 | GNAT family N-acetyltransferase | Toxin |
| KTV86_RS16520 (3428065) | 3428065..3428355 | - | 291 | WP_000855693.1 | DUF1778 domain-containing protein | Antitoxin |
| KTV86_RS16525 (3428625) | 3428625..3428814 | - | 190 | Protein_3224 | IS3 family transposase | - |
| KTV86_RS16530 (3429218) | 3429218..3429661 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| KTV86_RS16535 (3430117) | 3430117..3430767 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| KTV86_RS16540 (3430764) | 3430764..3432452 | + | 1689 | WP_000848115.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 3427292..3436080 | 8788 | |
| flank | IS/Tn | - | - | 3427292..3427468 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19041.85 Da Isoelectric Point: 9.6420
>T207748 WP_000971654.1 NZ_CP077760:c3428068-3427541 [Salmonella enterica subsp. enterica serovar Gallinarum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T207748 NZ_CP103503:c4678974-4678441 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10736.56 Da Isoelectric Point: 5.1088
>AT207748 WP_000855693.1 NZ_CP077760:c3428355-3428065 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERIYLTERDTQMIMEILDNPPEP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERIYLTERDTQMIMEILDNPPEP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT207748 NZ_CP103503:c4679251-4678985 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y9PNF0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B5RDM6 |