251196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1048669..1049483 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL732_RS05070 Protein ID WP_000971655.1
Coordinates 1048669..1049196 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL732_RS05075 Protein ID WP_000855694.1
Coordinates 1049193..1049483 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS05050 (1043971) 1043971..1046538 - 2568 WP_001005816.1 DNA mismatch repair protein MutS -
NL732_RS05055 (1046696) 1046696..1047217 + 522 WP_015633084.1 hypothetical protein -
NL732_RS05060 (1047388) 1047388..1048044 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
NL732_RS05065 (1048379) 1048379..1048596 + 218 Protein_993 IS5/IS1182 family transposase -
NL732_RS05070 (1048669) 1048669..1049196 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL732_RS05075 (1049193) 1049193..1049483 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL732_RS05080 (1049752) 1049752..1049930 - 179 Protein_996 IS3 family transposase -
NL732_RS05085 (1050171) 1050171..1050497 + 327 WP_000393302.1 hypothetical protein -
NL732_RS05090 (1050770) 1050770..1051117 - 348 WP_001555786.1 DUF1493 family protein -
NL732_RS05095 (1051102) 1051102..1051551 - 450 WP_000381608.1 hypothetical protein -
NL732_RS05100 (1051983) 1051983..1052426 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL732_RS05105 (1052882) 1052882..1053532 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1048420..1058845 10425
flank IS/Tn - - 1048420..1048596 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251196 WP_000971655.1 NZ_CP100718:c1049196-1048669 [Salmonella enterica subsp. enterica serovar Weltevreden]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251196 WP_000855694.1 NZ_CP100718:c1049483-1049193 [Salmonella enterica subsp. enterica serovar Weltevreden]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References