Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108722..1109536 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NMU39_RS05380 Protein ID WP_000971655.1
Coordinates 1108722..1109249 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag NMU39_RS05385 Protein ID WP_000855692.1
Coordinates 1109246..1109536 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS05360 (1104022) 1104022..1106589 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NMU39_RS05365 (1106748) 1106748..1107269 + 522 WP_000858988.1 hypothetical protein -
NMU39_RS05370 (1107441) 1107441..1108097 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NMU39_RS05375 (1108444) 1108444..1108649 + 206 Protein_1056 IS5/IS1182 family transposase -
NMU39_RS05380 (1108722) 1108722..1109249 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NMU39_RS05385 (1109246) 1109246..1109536 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
NMU39_RS05390 (1109806) 1109806..1109984 - 179 Protein_1059 IS3 family transposase -
NMU39_RS05395 (1110225) 1110225..1110551 + 327 WP_000393302.1 hypothetical protein -
NMU39_RS05400 (1110824) 1110824..1111171 - 348 WP_001669174.1 DUF1493 family protein -
NMU39_RS05405 (1111156) 1111156..1111605 - 450 WP_000381610.1 membrane protein -
NMU39_RS05410 (1112036) 1112036..1112479 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NMU39_RS05415 (1112936) 1112936..1113586 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1108473..1118899 10426
flank IS/Tn - - 1108473..1108649 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T252118 WP_000971655.1 NZ_CP101390:c1109249-1108722 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT252118 WP_000855692.1 NZ_CP101390:c1109536-1109246 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References