Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028007..1028821 Replicon chromosome
Accession NZ_CP047544
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN29_RS04940 Protein ID WP_000971655.1
Coordinates 1028007..1028534 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN29_RS04945 Protein ID WP_000855692.1
Coordinates 1028531..1028821 (-) Length 97 a.a.

Genomic Context

DXN29_RS04925DXN29_RS04935DXN29_RS04955DXN29_RS04975DXN29_RS04920DXN29_RS04930DXN29_RS04940DXN29_RS04945DXN29_RS04950DXN29_RS04960DXN29_RS04965DXN29_RS04970
Location: 1026033..1026554 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1027729..1027934 (206 bp)
Type: Others
Protein ID: Protein_971
Location: 1029510..1029836 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 1032221..1032871 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1023307..1025874 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1026726..1027382 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1028007..1028534 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 1028531..1028821 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 1029091..1029269 (179 bp)
Type: Others
Protein ID: Protein_974
Location: 1030109..1030456 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1030441..1030890 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 1031321..1031764 (444 bp)
Type: Others
Protein ID: WP_000715092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DXN29_RS04920 (1023307)1023307..1025874-2568WP_001005807.1DNA mismatch repair protein MutS-
DXN29_RS04925 (1026033)1026033..1026554+522WP_000858988.1hypothetical protein-
DXN29_RS04930 (1026726)1026726..1027382-657WP_000420452.1protein-serine/threonine phosphatase-
DXN29_RS04935 (1027729)1027729..1027934+206Protein_971IS5/IS1182 family transposase-
DXN29_RS04940 (1028007)1028007..1028534-528WP_000971655.1GNAT family N-acetyltransferaseToxin
DXN29_RS04945 (1028531)1028531..1028821-291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
DXN29_RS04950 (1029091)1029091..1029269-179Protein_974IS3 family transposase-
DXN29_RS04955 (1029510)1029510..1029836+327WP_000393302.1hypothetical protein-
DXN29_RS04960 (1030109)1030109..1030456-348WP_001669174.1DUF1493 family protein-
DXN29_RS04965 (1030441)1030441..1030890-450WP_000381610.1membrane protein-
DXN29_RS04970 (1031321)1031321..1031764-444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
DXN29_RS04975 (1032221)1032221..1032871+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1026726..103818411458
flankIS/Tn--1027758..1027934176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146567 WP_000971655.1 NZ_CP047544:c1028534-1028007 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146567 NZ_CP062762:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146567 WP_000855692.1 NZ_CP047544:c1028821-1028531 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146567 NZ_CP062762:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References