Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2941779..2942593 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q86_RS14460 Protein ID WP_000971655.1
Coordinates 2942066..2942593 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q86_RS14455 Protein ID WP_000855694.1
Coordinates 2941779..2942069 (+) Length 97 a.a.

Genomic Context

H9Q86_RS14445H9Q86_RS14450H9Q86_RS14455H9Q86_RS14460H9Q86_RS14470H9Q86_RS14435H9Q86_RS14440H9Q86_RS14465H9Q86_RS14475H9Q86_RS14480H9Q86_RS14485
Location: 2940473..2940916 (444 bp)
Type: Others
Protein ID: WP_000715097.1
Location: 2941320..2941509 (190 bp)
Type: Others
Protein ID: Protein_2823
Location: 2941779..2942069 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 2942066..2942593 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 2943230..2943886 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 2937682..2939370 (1689 bp)
Type: Others
Protein ID: WP_000848113.1
Location: 2939367..2940017 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 2942666..2942871 (206 bp)
Type: Others
Protein ID: Protein_2826
Location: 2944131..2944625 (495 bp)
Type: Others
Protein ID: WP_000424949.1
Location: 2944652..2945320 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 2945906..2946304 (399 bp)
Type: Others
Protein ID: Protein_2830
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H9Q86_RS14435 (2937682)2937682..2939370-1689WP_000848113.1type III secretion system outer membrane ring protein InvG-
H9Q86_RS14440 (2939367)2939367..2940017-651WP_001674874.1type III secretion system transcriptional activator InvF-
H9Q86_RS14445 (2940473)2940473..2940916+444WP_000715097.1SPI-1 type III secretion system invasion lipoprotein InvH-
H9Q86_RS14450 (2941320)2941320..2941509+190Protein_2823IS3 family transposase-
H9Q86_RS14455 (2941779)2941779..2942069+291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
H9Q86_RS14460 (2942066)2942066..2942593+528WP_000971655.1GNAT family N-acetyltransferaseToxin
H9Q86_RS14465 (2942666)2942666..2942871-206Protein_2826IS5/IS1182 family transposase-
H9Q86_RS14470 (2943230)2943230..2943886+657WP_000420452.1protein-serine/threonine phosphatase-
H9Q86_RS14475 (2944131)2944131..2944625-495WP_000424949.1hypothetical protein-
H9Q86_RS14480 (2944652)2944652..2945320-669WP_000445914.1hypothetical protein-
H9Q86_RS14485 (2945906)2945906..2946304-399Protein_2830cytoplasmic protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--2942666..2942842176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170607 WP_000971655.1 NZ_CP060670:2942066-2942593 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170607 NZ_CP077659:c2456345-2455992 [Enterobacter cloacae complex sp. ECL72]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAAAGGAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170607 WP_000855694.1 NZ_CP060670:2941779-2942069 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170607 NZ_CP077659:c2455987-2455685 [Enterobacter cloacae complex sp. ECL72]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References