170607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2941779..2942593 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag H9Q86_RS14460 Protein ID WP_000971655.1
Coordinates 2942066..2942593 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag H9Q86_RS14455 Protein ID WP_000855694.1
Coordinates 2941779..2942069 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS14435 (2937682) 2937682..2939370 - 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -
H9Q86_RS14440 (2939367) 2939367..2940017 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
H9Q86_RS14445 (2940473) 2940473..2940916 + 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
H9Q86_RS14450 (2941320) 2941320..2941509 + 190 Protein_2823 IS3 family transposase -
H9Q86_RS14455 (2941779) 2941779..2942069 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
H9Q86_RS14460 (2942066) 2942066..2942593 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
H9Q86_RS14465 (2942666) 2942666..2942871 - 206 Protein_2826 IS5/IS1182 family transposase -
H9Q86_RS14470 (2943230) 2943230..2943886 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
H9Q86_RS14475 (2944131) 2944131..2944625 - 495 WP_000424949.1 hypothetical protein -
H9Q86_RS14480 (2944652) 2944652..2945320 - 669 WP_000445914.1 hypothetical protein -
H9Q86_RS14485 (2945906) 2945906..2946304 - 399 Protein_2830 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2942666..2942842 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T170607 WP_000971655.1 NZ_CP060670:2942066-2942593 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T170607 NZ_CP077659:c2456345-2455992 [Enterobacter cloacae complex sp. ECL72]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAAAGGAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT170607 WP_000855694.1 NZ_CP060670:2941779-2942069 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT170607 NZ_CP077659:c2455987-2455685 [Enterobacter cloacae complex sp. ECL72]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References