Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3047339..3048153 Replicon chromosome
Accession NZ_CP074092
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KFK83_RS14895 Protein ID WP_000971655.1
Coordinates 3047626..3048153 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KFK83_RS14890 Protein ID WP_000855692.1
Coordinates 3047339..3047629 (+) Length 97 a.a.

Genomic Context

KFK83_RS14865KFK83_RS14870KFK83_RS14875KFK83_RS14885KFK83_RS14890KFK83_RS14895KFK83_RS14905KFK83_RS14915KFK83_RS14860KFK83_RS14880KFK83_RS14900KFK83_RS14910
Location: 3044396..3044839 (444 bp)
Type: Others
Protein ID: WP_000715092.1
Location: 3045270..3045719 (450 bp)
Type: Others
Protein ID: WP_000381610.1
Location: 3045704..3046051 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 3046891..3047069 (179 bp)
Type: Others
Protein ID: Protein_2922
Location: 3047339..3047629 (291 bp)
Type: Antitoxin
Protein ID: WP_000855692.1
Location: 3047626..3048153 (528 bp)
Type: Toxin
Protein ID: WP_000971655.1
Location: 3048778..3049434 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 3050286..3052853 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 3043289..3043939 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 3046324..3046650 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 3048226..3048431 (206 bp)
Type: Others
Protein ID: Protein_2925
Location: 3049606..3050127 (522 bp)
Type: Others
Protein ID: WP_000858988.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KFK83_RS14860 (3043289)3043289..3043939-651WP_001674874.1type III secretion system transcriptional activator InvF-
KFK83_RS14865 (3044396)3044396..3044839+444WP_000715092.1SPI-1 type III secretion system invasion lipoprotein InvH-
KFK83_RS14870 (3045270)3045270..3045719+450WP_000381610.1membrane protein-
KFK83_RS14875 (3045704)3045704..3046051+348WP_001669174.1DUF1493 family protein-
KFK83_RS14880 (3046324)3046324..3046650-327WP_000393302.1hypothetical protein-
KFK83_RS14885 (3046891)3046891..3047069+179Protein_2922IS3 family transposase-
KFK83_RS14890 (3047339)3047339..3047629+291WP_000855692.1DUF1778 domain-containing proteinAntitoxin
KFK83_RS14895 (3047626)3047626..3048153+528WP_000971655.1GNAT family N-acetyltransferaseToxin
KFK83_RS14900 (3048226)3048226..3048431-206Protein_2925IS5/IS1182 family transposase-
KFK83_RS14905 (3048778)3048778..3049434+657WP_000420452.1protein-serine/threonine phosphatase-
KFK83_RS14910 (3049606)3049606..3050127-522WP_000858988.1hypothetical protein-
KFK83_RS14915 (3050286)3050286..3052853+2568WP_001005807.1DNA mismatch repair protein MutS-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3048226..3048402176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T201376 WP_000971655.1 NZ_CP074092:3047626-3048153 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T201376 NZ_CP098347:c5096535-5095618 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT201376 WP_000855692.1 NZ_CP074092:3047339-3047629 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT201376 NZ_CP098347:c5097299-5096541 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6G96
PDB7AK9

Antitoxin

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Source
ID
Structure
PDB7AK9
AlphaFold DBA0A625WHV3

References