221445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2048292..2049106 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LJF56_RS09640 Protein ID WP_000971655.1
Coordinates 2048292..2048819 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJF56_RS09645 Protein ID WP_000855694.1
Coordinates 2048816..2049106 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS09615 (2044581) 2044581..2044979 + 399 Protein_1859 cytoplasmic protein -
LJF56_RS09620 (2045565) 2045565..2046233 + 669 WP_000445914.1 hypothetical protein -
LJF56_RS09625 (2046260) 2046260..2046754 + 495 WP_000424949.1 hypothetical protein -
LJF56_RS09630 (2046999) 2046999..2047655 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LJF56_RS09635 (2048014) 2048014..2048219 + 206 Protein_1863 IS5/IS1182 family transposase -
LJF56_RS09640 (2048292) 2048292..2048819 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LJF56_RS09645 (2048816) 2048816..2049106 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJF56_RS09650 (2049376) 2049376..2049565 - 190 Protein_1866 IS3 family transposase -
LJF56_RS09655 (2049969) 2049969..2050412 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJF56_RS09660 (2050868) 2050868..2051518 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LJF56_RS09665 (2051515) 2051515..2053203 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2048043..2048219 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T221445 WP_000971655.1 NZ_CP085797:c2048819-2048292 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T221445 NZ_CP117394:2019290-2019393 [Salmonella enterica subsp. enterica serovar Uganda]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT221445 WP_000855694.1 NZ_CP085797:c2049106-2048816 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT221445 NZ_CP117394:c2019395-2019252 [Salmonella enterica subsp. enterica serovar Uganda]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References