Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 996069..996883 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag MQF88_RS04750 Protein ID WP_000971655.1
Coordinates 996069..996596 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag MQF88_RS04755 Protein ID WP_000855692.1
Coordinates 996593..996883 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS04730 (991369) 991369..993936 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
MQF88_RS04735 (994095) 994095..994616 + 522 WP_000858988.1 hypothetical protein -
MQF88_RS04740 (994788) 994788..995444 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
MQF88_RS04745 (995791) 995791..995996 + 206 Protein_933 IS5/IS1182 family transposase -
MQF88_RS04750 (996069) 996069..996596 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
MQF88_RS04755 (996593) 996593..996883 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
MQF88_RS04760 (997153) 997153..997331 - 179 Protein_936 IS3 family transposase -
MQF88_RS04765 (997572) 997572..997898 + 327 WP_000393302.1 hypothetical protein -
MQF88_RS04770 (998171) 998171..998518 - 348 WP_001669174.1 DUF1493 family protein -
MQF88_RS04775 (998503) 998503..998952 - 450 WP_000381610.1 membrane protein -
MQF88_RS04780 (999383) 999383..999826 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MQF88_RS04785 (1000283) 1000283..1000933 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995820..1006246 10426
flank IS/Tn - - 995820..995996 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T239673 WP_000971655.1 NZ_CP094332:c996596-996069 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T239673 NZ_LS483301:c2319998-2319894 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT239673 WP_000855692.1 NZ_CP094332:c996883-996593 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT239673 NZ_LS483301:2319781-2319836 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References