251068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1013732..1014546 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL711_RS04915 Protein ID WP_000971655.1
Coordinates 1013732..1014259 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL711_RS04920 Protein ID WP_000855694.1
Coordinates 1014256..1014546 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS04895 (1009034) 1009034..1011601 - 2568 WP_001005816.1 DNA mismatch repair protein MutS -
NL711_RS04900 (1011759) 1011759..1012280 + 522 WP_015633084.1 hypothetical protein -
NL711_RS04905 (1012451) 1012451..1013107 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
NL711_RS04910 (1013442) 1013442..1013659 + 218 Protein_962 IS5/IS1182 family transposase -
NL711_RS04915 (1013732) 1013732..1014259 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL711_RS04920 (1014256) 1014256..1014546 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL711_RS04925 (1014815) 1014815..1014993 - 179 Protein_965 IS3 family transposase -
NL711_RS04930 (1015234) 1015234..1015560 + 327 WP_000393302.1 hypothetical protein -
NL711_RS04935 (1015833) 1015833..1016180 - 348 WP_001555786.1 DUF1493 family protein -
NL711_RS04940 (1016165) 1016165..1016614 - 450 WP_000381608.1 hypothetical protein -
NL711_RS04945 (1017046) 1017046..1017489 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL711_RS04950 (1017945) 1017945..1018595 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1013483..1023908 10425
flank IS/Tn - - 1013483..1013659 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251068 WP_000971655.1 NZ_CP100695:c1014259-1013732 [Salmonella enterica subsp. enterica serovar Weltevreden]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251068 WP_000855694.1 NZ_CP100695:c1014546-1014256 [Salmonella enterica subsp. enterica serovar Weltevreden]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References