Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3712786..3713600 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L0F61_RS18415 Protein ID WP_000971655.1
Coordinates 3713073..3713600 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L0F61_RS18410 Protein ID WP_000855692.1
Coordinates 3712786..3713076 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS18380 (3708736) 3708736..3709386 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
L0F61_RS18385 (3709843) 3709843..3710286 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L0F61_RS18390 (3710717) 3710717..3711166 + 450 WP_000381610.1 membrane protein -
L0F61_RS18395 (3711151) 3711151..3711498 + 348 WP_001669174.1 DUF1493 family protein -
L0F61_RS18400 (3711771) 3711771..3712097 - 327 WP_000393302.1 hypothetical protein -
L0F61_RS18405 (3712338) 3712338..3712516 + 179 Protein_3593 IS3 family transposase -
L0F61_RS18410 (3712786) 3712786..3713076 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L0F61_RS18415 (3713073) 3713073..3713600 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L0F61_RS18420 (3713673) 3713673..3713878 - 206 Protein_3596 IS5/IS1182 family transposase -
L0F61_RS18425 (3714225) 3714225..3714881 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
L0F61_RS18430 (3715053) 3715053..3715574 - 522 WP_000858988.1 hypothetical protein -
L0F61_RS18435 (3715733) 3715733..3718300 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3713673..3713849 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T231058 WP_000971655.1 NZ_CP090533:3713073-3713600 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T231058 NZ_CP125903:c854323-854135 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT231058 WP_000855692.1 NZ_CP090533:3712786-3713076 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT231058 NZ_CP125903:c854612-854352 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References