187174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4060747..4061561 Replicon chromosome
Accession NZ_CP068386
Organism Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag JI728_RS19785 Protein ID WP_000971654.1
Coordinates 4061034..4061561 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag JI728_RS19780 Protein ID WP_000855694.1
Coordinates 4060747..4061037 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI728_RS19760 (4056650) 4056650..4058338 - 1689 WP_000848115.1 type III secretion system outer membrane ring protein InvG -
JI728_RS19765 (4058335) 4058335..4058985 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
JI728_RS19770 (4059441) 4059441..4059884 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
JI728_RS19775 (4060288) 4060288..4060477 + 190 Protein_3874 IS3 family transposase -
JI728_RS19780 (4060747) 4060747..4061037 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
JI728_RS19785 (4061034) 4061034..4061561 + 528 WP_000971654.1 GNAT family N-acetyltransferase Toxin
JI728_RS19790 (4061634) 4061634..4061839 - 206 Protein_3877 IS5/IS1182 family transposase -
JI728_RS19795 (4062198) 4062198..4062854 + 657 WP_000420455.1 protein-serine/threonine phosphatase -
JI728_RS19800 (4063099) 4063099..4063593 - 495 WP_000424949.1 hypothetical protein -
JI728_RS19805 (4063620) 4063620..4064288 - 669 WP_000445914.1 hypothetical protein -
JI728_RS19810 (4064874) 4064874..4065272 - 399 Protein_3881 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4061634..4061810 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T187174 WP_000971654.1 NZ_CP068386:4061034-4061561 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T187174 NZ_CP089779:1193459-1193875 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT187174 WP_000855694.1 NZ_CP068386:4060747-4061037 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT187174 NZ_CP089779:1193196-1193462 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y9PNF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References