271142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 997799..998613 Replicon chromosome
Accession NZ_CP117398
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM015

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQQ09_RS04775 Protein ID WP_000971655.1
Coordinates 997799..998326 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQQ09_RS04780 Protein ID WP_000855692.1
Coordinates 998323..998613 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ09_RS04755 (993099) 993099..995666 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQQ09_RS04760 (995825) 995825..996346 + 522 WP_024159753.1 hypothetical protein -
PQQ09_RS04765 (996518) 996518..997174 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ09_RS04770 (997521) 997521..997726 + 206 Protein_935 IS5/IS1182 family transposase -
PQQ09_RS04775 (997799) 997799..998326 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQQ09_RS04780 (998323) 998323..998613 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQQ09_RS04785 (998883) 998883..999061 - 179 Protein_938 IS3 family transposase -
PQQ09_RS04790 (999302) 999302..999628 + 327 WP_000393302.1 hypothetical protein -
PQQ09_RS04795 (999901) 999901..1000248 - 348 WP_001669174.1 DUF1493 family protein -
PQQ09_RS04800 (1000233) 1000233..1000682 - 450 WP_000381610.1 membrane protein -
PQQ09_RS04805 (1001113) 1001113..1001556 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ09_RS04810 (1002013) 1002013..1002663 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 997550..1007976 10426
flank IS/Tn - - 997550..997726 176
inside Genomic island - invH / invF / invG / invE / invA / invB 996518..1007976 11458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T271142 WP_000971655.1 NZ_CP117398:c998326-997799 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT271142 WP_000855692.1 NZ_CP117398:c998613-998323 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References