276947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1003796..1004610 Replicon chromosome
Accession NZ_CP122457
Organism Salmonella enterica subsp. enterica strain TZ282

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag QCX26_RS04780 Protein ID WP_000971655.1
Coordinates 1003796..1004323 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QCX26_RS04785 Protein ID WP_000855694.1
Coordinates 1004320..1004610 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCX26_RS04750 (1000157) 1000157..1000555 + 399 Protein_930 cytoplasmic protein -
QCX26_RS04755 (1000746) 1000746..1000985 + 240 Protein_931 hypothetical protein -
QCX26_RS04760 (1001142) 1001142..1001810 + 669 WP_000445914.1 hypothetical protein -
QCX26_RS04765 (1001837) 1001837..1002331 + 495 WP_080184759.1 hypothetical protein -
QCX26_RS04770 (1002503) 1002503..1003159 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
QCX26_RS04775 (1003518) 1003518..1003723 + 206 Protein_935 IS5/IS1182 family transposase -
QCX26_RS04780 (1003796) 1003796..1004323 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
QCX26_RS04785 (1004320) 1004320..1004610 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QCX26_RS04790 (1004880) 1004880..1005069 - 190 Protein_938 IS3 family transposase -
QCX26_RS04795 (1005310) 1005310..1005636 + 327 WP_050067855.1 hypothetical protein -
QCX26_RS04800 (1005909) 1005909..1006256 - 348 WP_001555786.1 DUF1493 family protein -
QCX26_RS04805 (1006241) 1006241..1006690 - 450 WP_000381616.1 hypothetical protein -
QCX26_RS04810 (1007109) 1007109..1007552 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QCX26_RS04815 (1008009) 1008009..1008659 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1003547..1013972 10425
- flank IS/Tn - - 1003547..1003723 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276947 WP_000971655.1 NZ_CP122457:c1004323-1003796 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT276947 WP_000855694.1 NZ_CP122457:c1004610-1004320 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References