207404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 979060..979874 Replicon chromosome
Accession NZ_CP077670
Organism Salmonella enterica strain S90

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag KTP13_RS04680 Protein ID WP_023227563.1
Coordinates 979060..979587 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag KTP13_RS04685 Protein ID WP_072162154.1
Coordinates 979584..979874 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP13_RS04655 (975361) 975361..975759 + 399 Protein_910 cytoplasmic protein -
KTP13_RS04660 (976345) 976345..977013 + 669 WP_000445914.1 hypothetical protein -
KTP13_RS04665 (977040) 977040..977534 + 495 WP_023227564.1 hypothetical protein -
KTP13_RS04670 (977779) 977779..978435 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KTP13_RS04675 (978770) 978770..978987 + 218 Protein_914 IS5/IS1182 family transposase -
KTP13_RS04680 (979060) 979060..979587 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
KTP13_RS04685 (979584) 979584..979874 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
KTP13_RS04690 (980144) 980144..980322 - 179 Protein_917 IS3 family transposase -
KTP13_RS04695 (980563) 980563..980889 + 327 WP_000393302.1 hypothetical protein -
KTP13_RS04700 (981162) 981162..981509 - 348 WP_001669174.1 DUF1493 family protein -
KTP13_RS04705 (981494) 981494..981943 - 450 WP_000381610.1 membrane protein -
KTP13_RS04710 (982374) 982374..982817 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KTP13_RS04715 (983273) 983273..983923 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 978847..989236 10389
- flank IS/Tn - - 978847..978987 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T207404 WP_023227563.1 NZ_CP077670:c979587-979060 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T207404 NZ_CP102977:c2066616-2066407 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT207404 WP_072162154.1 NZ_CP077670:c979874-979584 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT207404 NZ_CP102977:c2066921-2066628 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References