Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1343255..1344069 Replicon chromosome
Accession NZ_CP121075
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.2574

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I05_RS06470 Protein ID WP_023994249.1
Coordinates 1343255..1343782 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I05_RS06475 Protein ID WP_000855694.1
Coordinates 1343779..1344069 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I05_RS06450 (1338556) 1338556..1341123 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P8I05_RS06455 (1341282) 1341282..1341803 + 522 WP_023994250.1 hypothetical protein -
P8I05_RS06460 (1341974) 1341974..1342630 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
P8I05_RS06465 (1342965) 1342965..1343182 + 218 Protein_1252 IS5/IS1182 family transposase -
P8I05_RS06470 (1343255) 1343255..1343782 - 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
P8I05_RS06475 (1343779) 1343779..1344069 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P8I05_RS06480 (1344339) 1344339..1344517 - 179 Protein_1255 IS3 family transposase -
P8I05_RS06485 (1344758) 1344758..1345084 + 327 WP_000393300.1 hypothetical protein -
P8I05_RS06490 (1345357) 1345357..1345704 - 348 WP_001669174.1 DUF1493 family protein -
P8I05_RS06495 (1345689) 1345689..1346138 - 450 WP_000381612.1 membrane protein -
P8I05_RS06500 (1346570) 1346570..1347013 - 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8I05_RS06505 (1347469) 1347469..1348119 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1343042..1353432 10390
- flank IS/Tn - - 1343042..1343182 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275622 WP_023994249.1 NZ_CP121075:c1343782-1343255 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275622 WP_000855694.1 NZ_CP121075:c1344069-1343779 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References