251325

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1012468..1013282 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag FGU68_RS04870 Protein ID WP_000971655.1
Coordinates 1012468..1012995 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag FGU68_RS04875 Protein ID WP_000855694.1
Coordinates 1012992..1013282 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS04840 (1008750) 1008750..1009148 + 399 Protein_948 cytoplasmic protein -
FGU68_RS04845 (1009339) 1009339..1009578 + 240 Protein_949 hypothetical protein -
FGU68_RS04850 (1009735) 1009735..1010403 + 669 WP_000445914.1 hypothetical protein -
FGU68_RS04855 (1010430) 1010430..1010924 + 495 WP_000424948.1 hypothetical protein -
FGU68_RS04860 (1011096) 1011096..1011752 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
FGU68_RS04865 (1011985) 1011985..1012395 + 411 Protein_953 transposase -
FGU68_RS04870 (1012468) 1012468..1012995 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
FGU68_RS04875 (1012992) 1012992..1013282 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
FGU68_RS04880 (1013552) 1013552..1013730 - 179 Protein_956 IS3 family transposase -
FGU68_RS04885 (1013971) 1013971..1014297 + 327 WP_000393302.1 hypothetical protein -
FGU68_RS04890 (1014570) 1014570..1014917 - 348 WP_001669174.1 DUF1493 family protein -
FGU68_RS04895 (1014902) 1014902..1015351 - 450 WP_000381610.1 membrane protein -
FGU68_RS04900 (1015783) 1015783..1016226 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
FGU68_RS04905 (1016682) 1016682..1017332 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1011096..1022645 11549
- flank IS/Tn - - 1012171..1012395 224
inside Genomic island - invH / invF / invG / invE / invA / invB 1012171..1022645 10474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251325 WP_000971655.1 NZ_CP100744:c1012995-1012468 [Salmonella enterica subsp. enterica serovar Newport]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251325 WP_000855694.1 NZ_CP100744:c1013282-1012992 [Salmonella enterica subsp. enterica serovar Newport]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References