275578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1014056..1014870 Replicon chromosome
Accession NZ_CP121070
Organism Salmonella enterica subsp. enterica serovar Infantis strain R22.0044

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I10_RS04840 Protein ID WP_023994249.1
Coordinates 1014056..1014583 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I10_RS04845 Protein ID WP_000855694.1
Coordinates 1014580..1014870 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I10_RS04820 (1009357) 1009357..1011924 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P8I10_RS04825 (1012083) 1012083..1012604 + 522 WP_023994250.1 hypothetical protein -
P8I10_RS04830 (1012775) 1012775..1013431 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
P8I10_RS04835 (1013766) 1013766..1013983 + 218 Protein_946 IS5/IS1182 family transposase -
P8I10_RS04840 (1014056) 1014056..1014583 - 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
P8I10_RS04845 (1014580) 1014580..1014870 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P8I10_RS04850 (1015140) 1015140..1015318 - 179 Protein_949 IS3 family transposase -
P8I10_RS04855 (1015559) 1015559..1015885 + 327 WP_000393300.1 hypothetical protein -
P8I10_RS04860 (1016158) 1016158..1016505 - 348 WP_001669174.1 DUF1493 family protein -
P8I10_RS04865 (1016490) 1016490..1016939 - 450 WP_000381612.1 membrane protein -
P8I10_RS04870 (1017371) 1017371..1017814 - 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8I10_RS04875 (1018270) 1018270..1018920 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1013843..1024233 10390
- flank IS/Tn - - 1013843..1013983 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275578 WP_023994249.1 NZ_CP121070:c1014583-1014056 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275578 WP_000855694.1 NZ_CP121070:c1014870-1014580 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References