271061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 990788..991602 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag PQP88_RS04810 Protein ID WP_000971658.1
Coordinates 990788..991315 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP88_RS04815 Protein ID WP_000855694.1
Coordinates 991312..991602 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS04780 (986999) 986999..987396 + 398 Protein_935 cytoplasmic protein -
PQP88_RS04785 (987587) 987587..987775 + 189 Protein_936 hypothetical protein -
PQP88_RS04790 (987983) 987983..988651 + 669 WP_000445914.1 hypothetical protein -
PQP88_RS04795 (988678) 988678..989172 + 495 WP_000424948.1 hypothetical protein -
PQP88_RS04800 (989417) 989417..990073 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP88_RS04805 (990306) 990306..990715 + 410 Protein_940 IS5/IS1182 family transposase -
PQP88_RS04810 (990788) 990788..991315 - 528 WP_000971658.1 GNAT family N-acetyltransferase Toxin
PQP88_RS04815 (991312) 991312..991602 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQP88_RS04820 (991872) 991872..992072 - 201 Protein_943 IS3 family transposase -
PQP88_RS04825 (992313) 992313..992639 + 327 WP_000393305.1 hypothetical protein -
PQP88_RS04830 (992912) 992912..993259 - 348 WP_001669174.1 DUF1493 family protein -
PQP88_RS04835 (993244) 993244..993693 - 450 WP_000381612.1 membrane protein -
PQP88_RS04840 (994125) 994125..994568 - 444 WP_079798511.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP88_RS04845 (995024) 995024..995674 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 990575..1000987 10412
- flank IS/Tn - - 990575..990715 140
- inside Genomic island - invH / invF / invG / invE / invA / invB 989417..1000987 11570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T271061 WP_000971658.1 NZ_CP117390:c991315-990788 [Salmonella enterica subsp. enterica serovar Uganda]
MMFTEWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT271061 WP_000855694.1 NZ_CP117390:c991602-991312 [Salmonella enterica subsp. enterica serovar Uganda]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References