Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1013694..1014508 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I08_RS04835 Protein ID WP_023994249.1
Coordinates 1013694..1014221 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I08_RS04840 Protein ID WP_000855694.1
Coordinates 1014218..1014508 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I08_RS04815 (1008995) 1008995..1011562 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P8I08_RS04820 (1011721) 1011721..1012242 + 522 WP_023994250.1 hypothetical protein -
P8I08_RS04825 (1012413) 1012413..1013069 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
P8I08_RS04830 (1013404) 1013404..1013621 + 218 Protein_945 IS5/IS1182 family transposase -
P8I08_RS04835 (1013694) 1013694..1014221 - 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
P8I08_RS04840 (1014218) 1014218..1014508 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P8I08_RS04845 (1014778) 1014778..1014956 - 179 Protein_948 IS3 family transposase -
P8I08_RS04850 (1015197) 1015197..1015523 + 327 WP_000393300.1 hypothetical protein -
P8I08_RS04855 (1015796) 1015796..1016143 - 348 WP_001669174.1 DUF1493 family protein -
P8I08_RS04860 (1016128) 1016128..1016577 - 450 WP_000381612.1 membrane protein -
P8I08_RS04865 (1017009) 1017009..1017452 - 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8I08_RS04870 (1017908) 1017908..1018558 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1013481..1023871 10390
- flank IS/Tn - - 1013481..1013621 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275557 WP_023994249.1 NZ_CP121068:c1014221-1013694 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275557 WP_000855694.1 NZ_CP121068:c1014508-1014218 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References