Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1013694..1014508 Replicon chromosome
Accession NZ_CP121068
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1575

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I08_RS04835 Protein ID WP_023994249.1
Coordinates 1013694..1014221 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I08_RS04840 Protein ID WP_000855694.1
Coordinates 1014218..1014508 (-) Length 97 a.a.

Genomic Context

P8I08_RS04820P8I08_RS04830P8I08_RS04850P8I08_RS04870P8I08_RS04815P8I08_RS04825P8I08_RS04835P8I08_RS04840P8I08_RS04845P8I08_RS04855P8I08_RS04860P8I08_RS04865
Location: 1011721..1012242 (522 bp)
Type: Others
Protein ID: WP_023994250.1
Location: 1013404..1013621 (218 bp)
Type: Others
Protein ID: Protein_945
Location: 1015197..1015523 (327 bp)
Type: Others
Protein ID: WP_000393300.1
Location: 1017908..1018558 (651 bp)
Type: Others
Protein ID: WP_001728903.1
Location: 1008995..1011562 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1012413..1013069 (657 bp)
Type: Others
Protein ID: WP_000420451.1
Location: 1013694..1014221 (528 bp)
Type: Toxin
Protein ID: WP_023994249.1
Location: 1014218..1014508 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 1014778..1014956 (179 bp)
Type: Others
Protein ID: Protein_948
Location: 1015796..1016143 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1016128..1016577 (450 bp)
Type: Others
Protein ID: WP_000381612.1
Location: 1017009..1017452 (444 bp)
Type: Others
Protein ID: WP_023993678.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P8I08_RS04815 (1008995)1008995..1011562-2568WP_001005807.1DNA mismatch repair protein MutS-
P8I08_RS04820 (1011721)1011721..1012242+522WP_023994250.1hypothetical protein-
P8I08_RS04825 (1012413)1012413..1013069-657WP_000420451.1protein-serine/threonine phosphatase-
P8I08_RS04830 (1013404)1013404..1013621+218Protein_945IS5/IS1182 family transposase-
P8I08_RS04835 (1013694)1013694..1014221-528WP_023994249.1GNAT family N-acetyltransferaseToxin
P8I08_RS04840 (1014218)1014218..1014508-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
P8I08_RS04845 (1014778)1014778..1014956-179Protein_948IS3 family transposase-
P8I08_RS04850 (1015197)1015197..1015523+327WP_000393300.1hypothetical protein-
P8I08_RS04855 (1015796)1015796..1016143-348WP_001669174.1DUF1493 family protein-
P8I08_RS04860 (1016128)1016128..1016577-450WP_000381612.1membrane protein-
P8I08_RS04865 (1017009)1017009..1017452-444WP_023993678.1SPI-1 type III secretion system invasion lipoprotein InvH-
P8I08_RS04870 (1017908)1017908..1018558+651WP_001728903.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1013481..102387110390
-flankIS/Tn--1013481..1013621140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275557 WP_023994249.1 NZ_CP121068:c1014221-1013694 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275557 WP_000855694.1 NZ_CP121068:c1014508-1014218 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5T8FHB0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References