258112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1000680..1001494 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4229_RS04760 Protein ID WP_000971655.1
Coordinates 1000680..1001207 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4229_RS04765 Protein ID WP_000855694.1
Coordinates 1001204..1001494 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS04730 (996980) 996980..997378 + 399 Protein_927 cytoplasmic protein -
N4229_RS04735 (997569) 997569..997808 + 240 Protein_928 hypothetical protein -
N4229_RS04740 (997965) 997965..998633 + 669 WP_000445914.1 hypothetical protein -
N4229_RS04745 (998660) 998660..999154 + 495 WP_020899151.1 hypothetical protein -
N4229_RS04750 (999399) 999399..1000055 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4229_RS04755 (1000402) 1000402..1000607 + 206 Protein_932 IS5/IS1182 family transposase -
N4229_RS04760 (1000680) 1000680..1001207 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4229_RS04765 (1001204) 1001204..1001494 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4229_RS04770 (1001764) 1001764..1001953 - 190 Protein_935 IS3 family transposase -
N4229_RS04775 (1002194) 1002194..1002520 + 327 WP_050067855.1 hypothetical protein -
N4229_RS04780 (1002793) 1002793..1003140 - 348 WP_001669174.1 DUF1493 family protein -
N4229_RS04785 (1003125) 1003125..1003574 - 450 WP_050067853.1 hypothetical protein -
N4229_RS04790 (1004006) 1004006..1004449 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4229_RS04795 (1004906) 1004906..1005556 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1000431..1010869 10438
- flank IS/Tn - - 1000431..1000607 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258112 WP_000971655.1 NZ_CP104491:c1001207-1000680 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258112 WP_000855694.1 NZ_CP104491:c1001494-1001204 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References