Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1126202..1127016 | Replicon | chromosome |
| Accession | NZ_CP096118 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain 22 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A4Y6MAM1 |
| Locus tag | MZK41_RS05550 | Protein ID | WP_023227563.1 |
| Coordinates | 1126202..1126729 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | A0A4Y6M833 |
| Locus tag | MZK41_RS05555 | Protein ID | WP_072162154.1 |
| Coordinates | 1126726..1127016 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MZK41_RS05525 (1122503) | 1122503..1122901 | + | 399 | Protein_1086 | cytoplasmic protein | - |
| MZK41_RS05530 (1123487) | 1123487..1124155 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| MZK41_RS05535 (1124182) | 1124182..1124676 | + | 495 | WP_023227564.1 | hypothetical protein | - |
| MZK41_RS05540 (1124921) | 1124921..1125577 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| MZK41_RS05545 (1125912) | 1125912..1126129 | + | 218 | Protein_1090 | IS5/IS1182 family transposase | - |
| MZK41_RS05550 (1126202) | 1126202..1126729 | - | 528 | WP_023227563.1 | GNAT family N-acetyltransferase | Toxin |
| MZK41_RS05555 (1126726) | 1126726..1127016 | - | 291 | WP_072162154.1 | DUF1778 domain-containing protein | Antitoxin |
| MZK41_RS05560 (1127286) | 1127286..1127464 | - | 179 | Protein_1093 | IS3 family transposase | - |
| MZK41_RS05565 (1127705) | 1127705..1128031 | + | 327 | WP_000393302.1 | hypothetical protein | - |
| MZK41_RS05570 (1128304) | 1128304..1128651 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| MZK41_RS05575 (1128636) | 1128636..1129085 | - | 450 | WP_000381610.1 | membrane protein | - |
| MZK41_RS05580 (1129516) | 1129516..1129959 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| MZK41_RS05585 (1130415) | 1130415..1131065 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1124921..1136378 | 11457 | ||
| - | flank | IS/Tn | - | - | 1125989..1126129 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T242751 WP_023227563.1 NZ_CP096118:c1126729-1126202 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T242751 NZ_OW967178:3180739-3181125 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.54 Da Isoelectric Point: 8.5779
>AT242751 WP_072162154.1 NZ_CP096118:c1127016-1126726 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT242751 NZ_OW967178:3181115-3181444 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Y6MAM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Y6M833 |