275537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1013832..1014646 Replicon chromosome
Accession NZ_CP121066
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.0914

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P8I09_RS04840 Protein ID WP_023994249.1
Coordinates 1013832..1014359 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P8I09_RS04845 Protein ID WP_000855694.1
Coordinates 1014356..1014646 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8I09_RS04820 (1009133) 1009133..1011700 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P8I09_RS04825 (1011859) 1011859..1012380 + 522 WP_023994250.1 hypothetical protein -
P8I09_RS04830 (1012551) 1012551..1013207 - 657 WP_000420451.1 protein-serine/threonine phosphatase -
P8I09_RS04835 (1013542) 1013542..1013759 + 218 Protein_946 IS5/IS1182 family transposase -
P8I09_RS04840 (1013832) 1013832..1014359 - 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
P8I09_RS04845 (1014356) 1014356..1014646 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P8I09_RS04850 (1014916) 1014916..1015094 - 179 Protein_949 IS3 family transposase -
P8I09_RS04855 (1015335) 1015335..1015661 + 327 WP_000393300.1 hypothetical protein -
P8I09_RS04860 (1015934) 1015934..1016281 - 348 WP_001669174.1 DUF1493 family protein -
P8I09_RS04865 (1016266) 1016266..1016715 - 450 WP_000381612.1 membrane protein -
P8I09_RS04870 (1017147) 1017147..1017590 - 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P8I09_RS04875 (1018046) 1018046..1018696 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1013619..1024009 10390
- flank IS/Tn - - 1013619..1013759 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T275537 WP_023994249.1 NZ_CP121066:c1014359-1013832 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT275537 WP_000855694.1 NZ_CP121066:c1014646-1014356 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References