265884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 993001..993815 Replicon chromosome
Accession NZ_CP113534
Organism Salmonella enterica strain ZYX

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OXV08_RS04725 Protein ID WP_000971655.1
Coordinates 993001..993528 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag OXV08_RS04730 Protein ID WP_072162154.1
Coordinates 993525..993815 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV08_RS04705 (988303) 988303..990870 - 2568 WP_020437800.1 DNA mismatch repair protein MutS -
OXV08_RS04710 (991029) 991029..991549 + 521 Protein_923 cytoplasmic protein -
OXV08_RS04715 (991720) 991720..992376 - 657 WP_020839120.1 protein-serine/threonine phosphatase -
OXV08_RS04720 (992711) 992711..992928 + 218 Protein_925 IS5/IS1182 family transposase -
OXV08_RS04725 (993001) 993001..993528 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OXV08_RS04730 (993525) 993525..993815 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
OXV08_RS04735 (994085) 994085..994263 - 179 Protein_928 IS3 family transposase -
OXV08_RS04740 (994504) 994504..994830 + 327 WP_268653131.1 hypothetical protein -
OXV08_RS04745 (995103) 995103..995450 - 348 WP_001669174.1 DUF1493 family protein -
OXV08_RS04750 (995435) 995435..995889 - 455 Protein_931 hypothetical protein -
OXV08_RS04755 (996321) 996321..996764 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OXV08_RS04760 (997220) 997220..997870 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 991720..1003183 11463
- flank IS/Tn - - 992788..992928 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T265884 WP_000971655.1 NZ_CP113534:c993528-993001 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT265884 WP_072162154.1 NZ_CP113534:c993815-993525 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References