Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1101369..1102183 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag P6164_RS05340 Protein ID WP_023227563.1
Coordinates 1101369..1101896 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag P6164_RS05345 Protein ID WP_072162154.1
Coordinates 1101893..1102183 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS05315 (1097670) 1097670..1098068 + 399 Protein_1043 cytoplasmic protein -
P6164_RS05320 (1098654) 1098654..1099322 + 669 WP_000445914.1 hypothetical protein -
P6164_RS05325 (1099349) 1099349..1099843 + 495 WP_023227564.1 hypothetical protein -
P6164_RS05330 (1100088) 1100088..1100744 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
P6164_RS05335 (1101079) 1101079..1101296 + 218 Protein_1047 IS5/IS1182 family transposase -
P6164_RS05340 (1101369) 1101369..1101896 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
P6164_RS05345 (1101893) 1101893..1102183 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
P6164_RS05350 (1102453) 1102453..1102631 - 179 Protein_1050 IS3 family transposase -
P6164_RS05355 (1102872) 1102872..1103198 + 327 WP_000393302.1 hypothetical protein -
P6164_RS05360 (1103471) 1103471..1103818 - 348 WP_001669174.1 DUF1493 family protein -
P6164_RS05365 (1103803) 1103803..1104252 - 450 WP_000381610.1 membrane protein -
P6164_RS05370 (1104683) 1104683..1105126 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P6164_RS05375 (1105582) 1105582..1106232 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1100088..1111545 11457
- flank IS/Tn - - 1101156..1101296 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T276016 WP_023227563.1 NZ_CP121189:c1101896-1101369 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT276016 WP_072162154.1 NZ_CP121189:c1102183-1101893 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References