253054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4145605..4146419 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A7U1KVS1
Locus tag NP448_RS20375 Protein ID WP_058653211.1
Coordinates 4145605..4146132 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NP448_RS20380 Protein ID WP_000855694.1
Coordinates 4146129..4146419 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS20345 (4141807) 4141807..4142205 + 399 Protein_3962 cytoplasmic protein -
NP448_RS20350 (4142396) 4142396..4142635 + 240 Protein_3963 hypothetical protein -
NP448_RS20355 (4142792) 4142792..4143460 + 669 WP_000445914.1 hypothetical protein -
NP448_RS20360 (4143487) 4143487..4143981 + 495 WP_000424947.1 hypothetical protein -
NP448_RS20365 (4144226) 4144226..4144882 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NP448_RS20370 (4145112) 4145112..4145532 + 421 Protein_3967 IS5 family transposase -
NP448_RS20375 (4145605) 4145605..4146132 - 528 WP_058653211.1 GNAT family N-acetyltransferase Toxin
NP448_RS20380 (4146129) 4146129..4146419 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NP448_RS20385 (4146689) 4146689..4146867 - 179 Protein_3970 IS3 family transposase -
NP448_RS20390 (4147108) 4147108..4147434 + 327 WP_000393302.1 hypothetical protein -
NP448_RS20395 (4147707) 4147707..4148054 - 348 WP_001669174.1 DUF1493 family protein -
NP448_RS20400 (4148039) 4148039..4148488 - 450 WP_000381617.1 hypothetical protein -
NP448_RS20405 (4148920) 4148920..4149363 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NP448_RS20410 (4149819) 4149819..4150469 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 4145338..4155782 10444
- flank IS/Tn - - 4145338..4145532 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T253054 WP_058653211.1 NZ_CP101940:c4146132-4145605 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRINFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT253054 WP_000855694.1 NZ_CP101940:c4146419-4146129 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KVS1

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References