270698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1022892..1023706 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A633KU44
Locus tag PQQ11_RS04940 Protein ID WP_000971648.1
Coordinates 1022892..1023419 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQQ11_RS04945 Protein ID WP_000855694.1
Coordinates 1023416..1023706 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS04920 (1018102) 1018102..1020669 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQQ11_RS04925 (1020828) 1020828..1021349 + 522 WP_000858988.1 hypothetical protein -
PQQ11_RS04930 (1021521) 1021521..1022177 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ11_RS04935 (1022410) 1022410..1022819 + 410 Protein_968 IS5/IS1182 family transposase -
PQQ11_RS04940 (1022892) 1022892..1023419 - 528 WP_000971648.1 GNAT family N-acetyltransferase Toxin
PQQ11_RS04945 (1023416) 1023416..1023706 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQQ11_RS04950 (1023976) 1023976..1024154 - 179 Protein_971 IS3 family transposase -
PQQ11_RS04955 (1024395) 1024395..1024721 + 327 WP_000393301.1 hypothetical protein -
PQQ11_RS04960 (1024994) 1024994..1025341 - 348 WP_001669174.1 DUF1493 family protein -
PQQ11_RS04965 (1025326) 1025326..1025775 - 450 WP_000381611.1 hypothetical protein -
PQQ11_RS04970 (1026207) 1026207..1026650 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ11_RS04975 (1027107) 1027107..1027757 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1022679..1033070 10391
- flank IS/Tn - - 1022679..1022819 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19040.90 Da        Isoelectric Point: 9.3905

>T270698 WP_000971648.1 NZ_CP117348:c1023419-1022892 [Salmonella enterica subsp. enterica serovar Heidelberg]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDITRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270698 WP_000855694.1 NZ_CP117348:c1023706-1023416 [Salmonella enterica subsp. enterica serovar Heidelberg]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A633KU44

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References