Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1022892..1023706 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A633KU44
Locus tag PQQ11_RS04940 Protein ID WP_000971648.1
Coordinates 1022892..1023419 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQQ11_RS04945 Protein ID WP_000855694.1
Coordinates 1023416..1023706 (-) Length 97 a.a.

Genomic Context

PQQ11_RS04925PQQ11_RS04935PQQ11_RS04955PQQ11_RS04975PQQ11_RS04920PQQ11_RS04930PQQ11_RS04940PQQ11_RS04945PQQ11_RS04950PQQ11_RS04960PQQ11_RS04965PQQ11_RS04970
Location: 1020828..1021349 (522 bp)
Type: Others
Protein ID: WP_000858988.1
Location: 1022410..1022819 (410 bp)
Type: Others
Protein ID: Protein_968
Location: 1024395..1024721 (327 bp)
Type: Others
Protein ID: WP_000393301.1
Location: 1027107..1027757 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 1018102..1020669 (2568 bp)
Type: Others
Protein ID: WP_001005807.1
Location: 1021521..1022177 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 1022892..1023419 (528 bp)
Type: Toxin
Protein ID: WP_000971648.1
Location: 1023416..1023706 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 1023976..1024154 (179 bp)
Type: Others
Protein ID: Protein_971
Location: 1024994..1025341 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 1025326..1025775 (450 bp)
Type: Others
Protein ID: WP_000381611.1
Location: 1026207..1026650 (444 bp)
Type: Others
Protein ID: WP_000715096.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PQQ11_RS04920 (1018102)1018102..1020669-2568WP_001005807.1DNA mismatch repair protein MutS-
PQQ11_RS04925 (1020828)1020828..1021349+522WP_000858988.1hypothetical protein-
PQQ11_RS04930 (1021521)1021521..1022177-657WP_000420452.1protein-serine/threonine phosphatase-
PQQ11_RS04935 (1022410)1022410..1022819+410Protein_968IS5/IS1182 family transposase-
PQQ11_RS04940 (1022892)1022892..1023419-528WP_000971648.1GNAT family N-acetyltransferaseToxin
PQQ11_RS04945 (1023416)1023416..1023706-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
PQQ11_RS04950 (1023976)1023976..1024154-179Protein_971IS3 family transposase-
PQQ11_RS04955 (1024395)1024395..1024721+327WP_000393301.1hypothetical protein-
PQQ11_RS04960 (1024994)1024994..1025341-348WP_001669174.1DUF1493 family protein-
PQQ11_RS04965 (1025326)1025326..1025775-450WP_000381611.1hypothetical protein-
PQQ11_RS04970 (1026207)1026207..1026650-444WP_000715096.1SPI-1 type III secretion system invasion lipoprotein InvH-
PQQ11_RS04975 (1027107)1027107..1027757+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB1022679..103307010391
-flankIS/Tn--1022679..1022819140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19040.90 Da        Isoelectric Point: 9.3905

>T270698 WP_000971648.1 NZ_CP117348:c1023419-1022892 [Salmonella enterica subsp. enterica serovar Heidelberg]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDITRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270698 WP_000855694.1 NZ_CP117348:c1023706-1023416 [Salmonella enterica subsp. enterica serovar Heidelberg]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A633KU44

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References