Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1255831..1256645 | Replicon | chromosome |
| Accession | NZ_CP085983 | ||
| Organism | Salmonella enterica strain SZL 31 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A5T8FHB0 |
| Locus tag | LJY15_RS06070 | Protein ID | WP_023994249.1 |
| Coordinates | 1255831..1256358 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | LJY15_RS06075 | Protein ID | WP_000855694.1 |
| Coordinates | 1256355..1256645 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJY15_RS06050 (1251132) | 1251132..1253699 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
| LJY15_RS06055 (1253858) | 1253858..1254379 | + | 522 | WP_023994250.1 | hypothetical protein | - |
| LJY15_RS06060 (1254550) | 1254550..1255206 | - | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
| LJY15_RS06065 (1255541) | 1255541..1255758 | + | 218 | Protein_1176 | IS5/IS1182 family transposase | - |
| LJY15_RS06070 (1255831) | 1255831..1256358 | - | 528 | WP_023994249.1 | GNAT family N-acetyltransferase | Toxin |
| LJY15_RS06075 (1256355) | 1256355..1256645 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| LJY15_RS06080 (1256915) | 1256915..1257093 | - | 179 | Protein_1179 | IS3 family transposase | - |
| LJY15_RS06085 (1257334) | 1257334..1257660 | + | 327 | WP_000393300.1 | hypothetical protein | - |
| LJY15_RS06090 (1257933) | 1257933..1258280 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| LJY15_RS06095 (1258265) | 1258265..1258714 | - | 450 | WP_000381612.1 | membrane protein | - |
| LJY15_RS06100 (1259146) | 1259146..1259589 | - | 444 | WP_023993678.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| LJY15_RS06105 (1260045) | 1260045..1260695 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1255618..1266008 | 10390 | ||
| - | flank | IS/Tn | - | - | 1255618..1255758 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19025.89 Da Isoelectric Point: 9.6423
>T222385 WP_023994249.1 NZ_CP085983:c1256358-1255831 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T222385 NZ_CP117838:3592173-3592472 [Enterobacter sp. S-33]
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATCCCTTCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGCAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGCTATTCCTCCATCCGGGTAAACAGGCAATACAGGCTCGTATTTTGCTGG
ACAGAGGGTAAAGCAGAAGATCTGTACCTCTCTCCACACAAGTACACGCAACACAAGTGA
ATGATTAGTTATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGCAGATCGAGCAATGTTATCCCTTCAAATCT
GGAAACAGCGCTTGCGAGAAAGCTCGATATCATCAGGGCAGCAACCTCGCACAGGGATTTGCGATCGCCACCGGGCAATA
TGTATGAAGCATTGAATCCTCCGCTGAAGGGCTATTCCTCCATCCGGGTAAACAGGCAATACAGGCTCGTATTTTGCTGG
ACAGAGGGTAAAGCAGAAGATCTGTACCTCTCTCCACACAAGTACACGCAACACAAGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT222385 WP_000855694.1 NZ_CP085983:c1256645-1256355 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT222385 NZ_CP117838:3592483-3592830 [Enterobacter sp. S-33]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCATCGCAACACCATCAGCGCGCTGGTCAATAACAATCGCAAGCTTA
CTGCCGATATGGCGATCAAGCTGGCAAAAGCCTTTGATACCACGATTGAATTCTGGCTGAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCTAACGCCAGGACGCAGGAGGAACTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAACCGGATGTAGCCTGA
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTCAATGTTCATCGCAACACCATCAGCGCGCTGGTCAATAACAATCGCAAGCTTA
CTGCCGATATGGCGATCAAGCTGGCAAAAGCCTTTGATACCACGATTGAATTCTGGCTGAACTTACAGCTGAACGTCGAT
ATCTGGGAAGCGCAATCTAACGCCAGGACGCAGGAGGAACTAAGCCGTATAAAGACCGTTGCGGACGTCATGGCTAAGCG
AAAATCTGGCCAACCGGATGTAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8FHB0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |