Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 954068..954882 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag CIC23_RS04535 Protein ID WP_000971654.1
Coordinates 954068..954595 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag CIC23_RS04540 Protein ID WP_000855694.1
Coordinates 954592..954882 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC23_RS04505 (950361) 950361..950759 + 399 Protein_884 cytoplasmic protein -
CIC23_RS04510 (950978) 950978..951196 + 219 Protein_885 hypothetical protein -
CIC23_RS04515 (951353) 951353..952021 + 669 WP_000445914.1 hypothetical protein -
CIC23_RS04520 (952048) 952048..952542 + 495 WP_000424948.1 hypothetical protein -
CIC23_RS04525 (952787) 952787..953443 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
CIC23_RS04530 (953772) 953772..953995 + 224 Protein_889 IS5/IS1182 family transposase -
CIC23_RS04535 (954068) 954068..954595 - 528 WP_000971654.1 GNAT family N-acetyltransferase Toxin
CIC23_RS04540 (954592) 954592..954882 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
CIC23_RS04545 (955152) 955152..955341 - 190 Protein_892 IS3 family transposase -
CIC23_RS04550 (955582) 955582..955908 + 327 WP_000393302.1 hypothetical protein -
CIC23_RS04555 (956181) 956181..956528 - 348 WP_001669174.1 DUF1493 family protein -
CIC23_RS04560 (956513) 956513..956962 - 450 WP_052929768.1 hypothetical protein -
CIC23_RS04565 (957393) 957393..957836 - 444 WP_052929766.1 SPI-1 type III secretion system invasion lipoprotein InvH -
CIC23_RS04570 (958292) 958292..958942 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 953819..964255 10436
- flank IS/Tn - - 953819..953995 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T202845 WP_000971654.1 NZ_CP075108:c954595-954068 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202845 NZ_CP099721:178593-178700 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT202845 WP_000855694.1 NZ_CP075108:c954882-954592 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202845 NZ_CP099721:c178536-178479 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y9PNF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References