Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 954068..954882 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag CIC23_RS04535 Protein ID WP_000971654.1
Coordinates 954068..954595 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag CIC23_RS04540 Protein ID WP_000855694.1
Coordinates 954592..954882 (-) Length 97 a.a.

Genomic Context

CIC23_RS04505CIC23_RS04510CIC23_RS04515CIC23_RS04520CIC23_RS04530CIC23_RS04550CIC23_RS04570CIC23_RS04525CIC23_RS04535CIC23_RS04540CIC23_RS04545CIC23_RS04555CIC23_RS04560CIC23_RS04565
Location: 950361..950759 (399 bp)
Type: Others
Protein ID: Protein_884
Location: 950978..951196 (219 bp)
Type: Others
Protein ID: Protein_885
Location: 951353..952021 (669 bp)
Type: Others
Protein ID: WP_000445914.1
Location: 952048..952542 (495 bp)
Type: Others
Protein ID: WP_000424948.1
Location: 953772..953995 (224 bp)
Type: Others
Protein ID: Protein_889
Location: 955582..955908 (327 bp)
Type: Others
Protein ID: WP_000393302.1
Location: 958292..958942 (651 bp)
Type: Others
Protein ID: WP_001674874.1
Location: 952787..953443 (657 bp)
Type: Others
Protein ID: WP_000420452.1
Location: 954068..954595 (528 bp)
Type: Toxin
Protein ID: WP_000971654.1
Location: 954592..954882 (291 bp)
Type: Antitoxin
Protein ID: WP_000855694.1
Location: 955152..955341 (190 bp)
Type: Others
Protein ID: Protein_892
Location: 956181..956528 (348 bp)
Type: Others
Protein ID: WP_001669174.1
Location: 956513..956962 (450 bp)
Type: Others
Protein ID: WP_052929768.1
Location: 957393..957836 (444 bp)
Type: Others
Protein ID: WP_052929766.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CIC23_RS04505 (950361)950361..950759+399Protein_884cytoplasmic protein-
CIC23_RS04510 (950978)950978..951196+219Protein_885hypothetical protein-
CIC23_RS04515 (951353)951353..952021+669WP_000445914.1hypothetical protein-
CIC23_RS04520 (952048)952048..952542+495WP_000424948.1hypothetical protein-
CIC23_RS04525 (952787)952787..953443-657WP_000420452.1protein-serine/threonine phosphatase-
CIC23_RS04530 (953772)953772..953995+224Protein_889IS5/IS1182 family transposase-
CIC23_RS04535 (954068)954068..954595-528WP_000971654.1GNAT family N-acetyltransferaseToxin
CIC23_RS04540 (954592)954592..954882-291WP_000855694.1DUF1778 domain-containing proteinAntitoxin
CIC23_RS04545 (955152)955152..955341-190Protein_892IS3 family transposase-
CIC23_RS04550 (955582)955582..955908+327WP_000393302.1hypothetical protein-
CIC23_RS04555 (956181)956181..956528-348WP_001669174.1DUF1493 family protein-
CIC23_RS04560 (956513)956513..956962-450WP_052929768.1hypothetical protein-
CIC23_RS04565 (957393)957393..957836-444WP_052929766.1SPI-1 type III secretion system invasion lipoprotein InvH-
CIC23_RS04570 (958292)958292..958942+651WP_001674874.1type III secretion system transcriptional activator InvF-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB953819..96425510436
-flankIS/Tn--953819..953995176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T202845 WP_000971654.1 NZ_CP075108:c954595-954068 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T202845 NZ_CP099721:178593-178700 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT202845 WP_000855694.1 NZ_CP075108:c954882-954592 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT202845 NZ_CP099721:c178536-178479 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5Y9PNF0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3V8SJE7

References