258948

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 956225..957039 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag N4534_RS04580 Protein ID WP_000971655.1
Coordinates 956225..956752 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4534_RS04585 Protein ID WP_000855694.1
Coordinates 956749..957039 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS04550 (952507) 952507..952905 + 399 Protein_890 cytoplasmic protein -
N4534_RS04555 (953096) 953096..953335 + 240 Protein_891 hypothetical protein -
N4534_RS04560 (953492) 953492..954160 + 669 WP_000445914.1 hypothetical protein -
N4534_RS04565 (954187) 954187..954681 + 495 WP_000424948.1 hypothetical protein -
N4534_RS04570 (954853) 954853..955509 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
N4534_RS04575 (955742) 955742..956152 + 411 Protein_895 transposase -
N4534_RS04580 (956225) 956225..956752 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
N4534_RS04585 (956749) 956749..957039 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4534_RS04590 (957309) 957309..957487 - 179 Protein_898 IS3 family transposase -
N4534_RS04595 (957728) 957728..958054 + 327 WP_000393302.1 hypothetical protein -
N4534_RS04600 (958327) 958327..958674 - 348 WP_001669174.1 DUF1493 family protein -
N4534_RS04605 (958659) 958659..959108 - 450 WP_000381610.1 membrane protein -
N4534_RS04610 (959540) 959540..959983 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4534_RS04615 (960439) 960439..961089 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 954853..966402 11549
- flank IS/Tn - - 955928..956152 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T258948 WP_000971655.1 NZ_CP104677:c956752-956225 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258948 WP_000855694.1 NZ_CP104677:c957039-956749 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References