Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 1024211..1025184 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name tacT Uniprot ID I6XA42
Locus tag Rv0919 Protein ID NP_215434.1
Coordinates 1024684..1025184 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag Rv0918 Protein ID NP_215433.1
Coordinates 1024211..1024687 (+) Length 159 a.a.

Genomic Context

Rv0917Rv0918Rv0919Rv0921Rv0922Rv0915cRv0916cRv0920c
Location: 1022087..1023868 (1782 bp)
Type: Others
Protein ID: NP_215432.1
Location: 1024211..1024687 (477 bp)
Type: Antitoxin
Protein ID: NP_215433.1
Location: 1024684..1025184 (501 bp)
Type: Toxin
Protein ID: NP_215434.1
Location: 1027104..1027685 (582 bp)
Type: Others
Protein ID: NP_215436.1
Location: 1027685..1029337 (1653 bp)
Type: Others
Protein ID: NP_215437.1
Location: 1020058..1021329 (1272 bp)
Type: Others
Protein ID: YP_177765.1
Location: 1021344..1021643 (300 bp)
Type: Others
Protein ID: YP_177766.1
Location: 1025497..1026816 (1320 bp)
Type: Others
Protein ID: NP_215435.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv0915c1020058..1021329-1272YP_177765.1PPE family protein PPE14-
Rv0916c1021344..1021643-300YP_177766.1PE family protein PE7-
Rv09171022087..1023868+1782NP_215432.1glycine betaine transport integral membrane protein BetP-
Rv09181024211..1024687+477NP_215433.1hypothetical proteinAntitoxin
Rv09191024684..1025184+501NP_215434.1GCN5-like N-acetyltransferaseToxin
Rv0920c1025497..1026816-1320NP_215435.1transposase-
Rv09211027104..1027685+582NP_215436.1resolvase-
Rv09221027685..1029337+1653NP_215437.1transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1023865..106977645911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T10041 NP_215434.1 NC_000962:1024684-1025184 [Mycobacterium tuberculosis H37Rv]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T10041 NC_000962:1024684-1025184 [Mycobacterium tuberculosis H37Rv]
GTGAGCGGCTACAGCGCGCCGCGACGTATCAGCGACGCCGATGACGTCACGAGCTTCAGCAGCGGCGAGCCCAGTCTGGA
CGATTACTTGCGCAAGCGGGCGTTGGCCAACCATGTGCAGGGAGGGTCGCGCTGTTTCGTGACGTGCCGTGACGGTCGGG
TAGTCGGCTTCTATGCGCTAGCGTCAGGGTCGGTCGCACACGCTGATGCTCCGGGACGGGTGCGCCGCAATATGCCTGAC
CCCGTGCCGGTGATCCTGCTGTCGCGGTTGGCGGTTGATCGCAAAGAACAGGGCAGGGGCCTGGGCAGTCATCTGCTGCG
TGATGCGATCGGTCGCTGTGTCCAGGCTGCGGACTCGATCGGGCTGCGGGCGATTCTTGTTCATGCGTTGCACGATGAGG
CCCGCGCGTTCTACGTCCACTTTGACTTCGAGATCTCGCCGACCGATCCGCTGCACCTAATGCTGTTGATGAAAGACGCT
CGCGCGCTAATTGGCGACTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT10041 NP_215433.1 NC_000962:1024211-1024687 [Mycobacterium tuberculosis H37Rv]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT10041 NC_000962:1024211-1024687 [Mycobacterium tuberculosis H37Rv]
TTGCACCGAGCGGGAGCGGCGGTGACGGCCAACGTGTGGTGTCGTGCGGGCGGCATTCGGATGGCGCCACGGCCGGTCAT
CCCGGTGGCTACGCAGCAGCGCCTGCGGCGGCAGGCGGATCGCCAGAGCCTGGGTAGTAGCGGCTTGCCAGCGTTGAATT
GTACGCCTATCAGGCACACAATTGATGTCATGGCTACCAAGCCTGAGCGGAAGACCGAGCGTCTTGCAGCGCGCCTGACC
CCTGAGCAGGACGCGCTGATTCGTCGTGCTGCCGAGGCCGAGGGGACTGACCTCACCAATTTCACGGTTACAGCGGCGTT
GGCGCACGCGCGCGACGTGCTGGCCGACCGCCGGCTCTTCGTACTCACCGATGCCGCGTGGACTGAGTTCCTCGCCGCGC
TGGACCGGCCCGTCTCACACAAGCCTCGGTTGGAGAAGCTGTTCGCCGCGCGGTCCATTTTCGACACCGAGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T443Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

50.327

95.031

0.478

T10051Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

46.795

95.706

0.448

T199Escherichia coli O157:H7 str. EDL933

39.61

95.652

0.379

T10052Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

33.121

94.578

0.313

T177Vibrio cholerae O1 biovar El Tor str. N16961

30.675

98.193

0.301
Showing 1 to 5 of 5 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT199Escherichia coli O157:H7 str. EDL933

40.789

80.851

0.33

AT443Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

37.349

87.368

0.326
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBI6XA42

Antitoxin

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Source
ID
Structure
AlphaFold DBO05910

References

(1) Francesca G Tomasi et al. (2022) A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. Microbiology Spectrum 10(3):e0058022. [PubMed:35638832] experimental


experimental experimental literature