Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1017789..1018408 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK02_RS04785 Protein ID WP_003404726.1
Coordinates 1017974..1018408 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPK02_RS04780 Protein ID WP_003898641.1
Coordinates 1017789..1017968 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK02_RS04765 1013262..1014842 + 1581 WP_003909313.1 serine hydrolase -
FPK02_RS04770 1014839..1017232 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
FPK02_RS04775 1017505..1017663 + 159 WP_003404720.1 hypothetical protein -
FPK02_RS04780 1017789..1017968 + 180 WP_003898641.1 antitoxin Antitoxin
FPK02_RS04785 1017974..1018408 + 435 WP_003404726.1 SRPBCC family protein Toxin
FPK02_RS04790 1018506..1019280 + 775 Protein_944 VOC family protein -
FPK02_RS04795 1019345..1019794 + 450 WP_003404738.1 hypothetical protein -
FPK02_RS04800 1019929..1020159 - 231 WP_003898642.1 hypothetical protein -
FPK02_RS04805 1020326..1021834 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
FPK02_RS04810 1021836..1023074 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1013154..1072885 59731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T130413 WP_003404726.1 NZ_CP041807:1017974-1018408 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T130413 NZ_CP041807:1017974-1018408 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT130413 WP_003898641.1 NZ_CP041807:1017789-1017968 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT130413 NZ_CP041807:1017789-1017968 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References