Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1017789..1018408 Replicon chromosome
Accession NZ_CP041807
Organism Mycobacterium tuberculosis strain SEA11020038P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK02_RS04785 Protein ID WP_003404726.1
Coordinates 1017974..1018408 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPK02_RS04780 Protein ID WP_003898641.1
Coordinates 1017789..1017968 (+) Length 60 a.a.

Genomic Context

FPK02_RS04765FPK02_RS04770FPK02_RS04775FPK02_RS04780FPK02_RS04785FPK02_RS04790FPK02_RS04795FPK02_RS04800FPK02_RS04805FPK02_RS04810
Location: 1013262..1014842 (1581 bp)
Type: Others
Protein ID: WP_003909313.1
Location: 1014839..1017232 (2394 bp)
Type: Others
Protein ID: WP_003898639.1
Location: 1017505..1017663 (159 bp)
Type: Others
Protein ID: WP_003404720.1
Location: 1017789..1017968 (180 bp)
Type: Antitoxin
Protein ID: WP_003898641.1
Location: 1017974..1018408 (435 bp)
Type: Toxin
Protein ID: WP_003404726.1
Location: 1018506..1019280 (775 bp)
Type: Others
Protein ID: Protein_944
Location: 1019345..1019794 (450 bp)
Type: Others
Protein ID: WP_003404738.1
Location: 1019929..1020159 (231 bp)
Type: Others
Protein ID: WP_003898642.1
Location: 1020326..1021834 (1509 bp)
Type: Others
Protein ID: WP_003404742.1
Location: 1021836..1023074 (1239 bp)
Type: Others
Protein ID: WP_003404744.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPK02_RS047651013262..1014842+1581WP_003909313.1serine hydrolase-
FPK02_RS047701014839..1017232+2394WP_003898639.1cation-translocating P-type ATPase-
FPK02_RS047751017505..1017663+159WP_003404720.1hypothetical protein-
FPK02_RS047801017789..1017968+180WP_003898641.1antitoxinAntitoxin
FPK02_RS047851017974..1018408+435WP_003404726.1SRPBCC family proteinToxin
FPK02_RS047901018506..1019280+775Protein_944VOC family protein-
FPK02_RS047951019345..1019794+450WP_003404738.1hypothetical protein-
FPK02_RS048001019929..1020159-231WP_003898642.1hypothetical protein-
FPK02_RS048051020326..1021834-1509WP_003404742.1carotenoid oxygenase family protein-
FPK02_RS048101021836..1023074-1239WP_003404744.1acetyl-CoA acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1013154..107288559731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T130413 WP_003404726.1 NZ_CP041807:1017974-1018408 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T130413 NZ_CP041807:1017974-1018408 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT130413 WP_003898641.1 NZ_CP041807:1017789-1017968 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT130413 NZ_CP041807:1017789-1017968 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A045KDK5

References