Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1017463..1018082 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK06_RS04785 Protein ID WP_003404726.1
Coordinates 1017648..1018082 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag FPK06_RS04780 Protein ID WP_003404724.1
Coordinates 1017463..1017642 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS04765 1012936..1014516 + 1581 WP_003909313.1 serine hydrolase -
FPK06_RS04770 1014513..1016906 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
FPK06_RS04775 1017179..1017337 + 159 WP_003404720.1 hypothetical protein -
FPK06_RS04780 1017463..1017642 + 180 WP_003404724.1 antitoxin Antitoxin
FPK06_RS04785 1017648..1018082 + 435 WP_003404726.1 SRPBCC family protein Toxin
FPK06_RS04790 1018180..1018953 + 774 WP_031719628.1 VOC family protein -
FPK06_RS04795 1019018..1019467 + 450 WP_003404738.1 hypothetical protein -
FPK06_RS04800 1019602..1019832 - 231 WP_003898642.1 hypothetical protein -
FPK06_RS04805 1019999..1021507 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
FPK06_RS04810 1021509..1022747 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1012828..1072558 59730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T130171 WP_003404726.1 NZ_CP041803:1017648-1018082 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T130171 NZ_CP041803:1017648-1018082 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT130171 WP_003404724.1 NZ_CP041803:1017463-1017642 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp

>AT130171 NZ_CP041803:1017463-1017642 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References